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Diss Factsheets
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EC number: 237-335-9 | CAS number: 13752-51-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Cure-rite 18 did not exhibit mutagenic activity in several assays with Salmonella and E. coli polA+. However, mutagenic effects were reported in several assays(commercial and purified) with E. coli polA-.
In the mouse lymphoma assay, positive repsonses were reported in several assays with mammalian metabolic activation.
Cure-rite 18 exhibited clastogenic activity activity in two assays using Chinese Hamster ovaries. Negative results were reported in one of those assays without mammalian metabolic acitivation. Without mammalian metabolic activation, the purified version exhibited a positive repsonse, while the commercial samples were negative.
Testing Proposal Waiver
According to the integrated testing strategy (R.7.7.6.3), testing beyond the standard set of in vitro tests is first directed towards investigating the potential for mutagenicity in somatic cells in vivo. Positive results in somatic cells in vivo consitute the trigger for consideration of investigation of potential expression of genotoxicity in germ cells. Waiving the in vivo somatic cell test (mouse micronucleus) is proposed since two in vivo germs cell studies and a carcinogenicity study have already been realised. Appropriate risk mamangement measures are in place based on the results of the carcinogenicity study. Realizing the in vivo somatic cell study would not change the risk mamangement measures in place. In three transformation assays, two positive and one negative response were reported. No effects were reported in two in-vivo dominant lethal assays.
Short description of key information:
Several genetic toxicity studies (in-vitro and in-vivo) are available giving mixed results.
Justification for classification or non-classification
Cure-rite 18 was not positive in the in-vivo dominant lethal assays.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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