Registration Dossier
Registration Dossier
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EC number: 938-774-5 | CAS number: 85408-49-7
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
No long-term fish toxicity studies have been performed using C12 -16 amine oxide. Data are read across from C12-14 on the basis of the equivalence in chemical structure, large overlap in chain length distributions between the substances and expected similarities in physico-chemical properties.
One long term (302 days) toxicity to fish study is available for C12-14 amine oxide. A no effect concentration of 0.42 mg AO/L was reported in the study.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 0.42 mg/L
Additional information
No long-term fish toxicity studies have been performed using C12 -16 amine oxide. Data are read across from C12-14 on the basis of the equivalence in chemical structure, large overlap in chain length distributions between the substances and expected similarities in physico-chemical properties.
In a full life-cycle toxicity test (similar to EPA OPPTS 850.1500) fathead minnows (Pimephales promelas) were exposed to C12 -14 AO for 302 days under flow through conditions [Aquatic Environmental Services (1976)]. The nominal test concentrations were 0, 0.06, 0.13, 0.25, 0.50, and 1.0 mg AO/L. Mean measured concentrations were 82 -117% of nominal. Endpoints included survival, growth, and hatchability. The NOEC was 0.42 mg AO/L (mean measured concentration), based on reduced fry survival, reduced egg hatch, and occluded eyes in test fish. This was consistent with results of a preliminary 15 -day test, in which the NOEC was 0.495 mg AO/L.
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