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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
05.10.1994 to 02.11.1994
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1995

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
not specified
GLP compliance:
yes
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Reference substance name:
checked and confirmed
IUPAC Name:
checked and confirmed
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder

Test animals

Species:
rat
Strain:
other: Chbb:THOM
Sex:
male/female

Administration / exposure

Route of administration:
other: ultra asept syringe and stomach tube
Vehicle:
water
Doses:
280, 400, 560, 800 amd 1100 mg/kg
No. of animals per sex per dose:
280 mg/kg: 5 male
400 mg/kg: 5 male
560 mg/kg: 5 male and 5 female
800 mg/kg: 5 male and 5 female
1100 mgKg: 5 female
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
approximate LD50
Effect level:
> 675 - < 1 100 mg/kg bw
Based on:
not specified
Mortality:
9 of 35 treated animals died.
Clinical signs:
Prone position, reduced motility, tachypnea, exophtalmia, ataxia, tremor, piloerection and others.
Body weight:
The body weight of all treated animals was reduced in the first week popst administration.
Gross pathology:
Congestion of lung and liver, enphysema of the lung, hemorrhages in the stomach mucosa, meteorism of the stomach and intestine, redding of the stomach mucosa and others.

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: OECD GHS
Conclusions:
SND 855 BS Y harmful by oral application.
Executive summary:

With an approximate LD50 675.2 mg/kg b.w. in males and > 1100 mg/kg b.w. in females after oral administration in rats the precursor 3 of SND 919 CL2 Y (SND 855 BS Y) could be classified as minortoxic.