Registration Dossier
Registration Dossier
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EC number: 200-935-6 | CAS number: 76-12-0
Endpoint summary
Administrative data
Description of key information
A reliable secondary source is reported as reference, which discusses the available literature data.
Basing on existing data 1,1,2,2 -tetrachloro-1,2 -difluoroethane does not meet the classification criteria for Skin and Eye Irritation/Corrosion.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation / corrosion
- Remarks:
- other: not documented
- Type of information:
- other: discussion based on literature data
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The source is considered reliable since reported information is based on a review of existing peer-reviewed scientific literature by committees of experts in public health and related sciences.
- Principles of method if other than guideline:
- discussion of literature data
- GLP compliance:
- not specified
- Species:
- other: Rabbit and Guinea pig
- Duration of treatment / exposure:
- one single exposure
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- 1,1,2,2-tetrachloro-1,2-difluoroethane does not meet the Regulation (EC) No. 1272/2008 classification criteria for skin irritation/corrosion.
- Executive summary:
The American Conference of Governmental Industrial Hygienists(ACGIH) is a professional association of industrial hygienists and practitioners of related professions. One of the goals of the association is to provide information and guideline on exposure limits of substances in order to advance worker protection.
ACGIH sheets are based on a review of existing peer-reviewed scientific literature by committees of experts in public health and related sciences and therefore ACGIH is considered a reliable secondary source of information.
According to the ACGIH sheet, slight transient redness was seen in rabbits following application of 0.5 ml to the skin. (DuPont Company, 1947, 1963) and mild irritation was seen when 1,1,2,2 -tetrachloro-1,2-difluoroethane was applied dermally to the skin of guinea pigs. (Clayton et al, 1966). These slight and transient signs of irritation are not sufficient to support a classification for Skin Irritation/Corrosion. Moreover this conclusion is supported by the Acute dermal toxicity study on rabbits (test material administered undiluted, 4h).
Reference
Slight transient redness was seen in rabbits following application of 0.5 ml to the skin. (DuPont Company, 1947, 1963)
Mild irritation was seen when 1,1,2,2 -tetrachloro-1,2-difluoroethane was applied dermally to the skin of guinea pigs. (Clayton et al, 1966)
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation
- Remarks:
- no data
- Type of information:
- other: discussion based on literature data
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The source is considered reliable since reported information is based on a review of existing peer-reviewed scientific literature by committees of experts in public health and related sciences.
- Principles of method if other than guideline:
- not documented
- GLP compliance:
- not specified
- Species:
- rabbit
- Remarks on result:
- other: only slight irritation was seen when 1,1,2,2-tetrachloro-1,2-difluoroethane was placed in the rabbit eye.
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- 1,1,2,2-tetrachloro-1,2-difluoroethane does not meet the Regulation (EC) No. 1272/2008 classification criteria for Serious Eye Damage/Eye Irritation.
- Executive summary:
The American Conference of Governmental Industrial Hygienists(ACGIH) is a professional association of industrial hygienists and practitioners of related professions. One of the goals of the association is to provide information and guideline on exposure limits of substances in order to advance worker protection.
ACGIH sheets are based on a review of existing peer-reviewed scientific literature by committees of experts in public health and related sciences and therefore ACGIH is considered a reliable secondary source of information.
According to the ACGIH sheet, only slight irritation was seen when 1,1,2,2-tetrachloro-1,2-difluoroethane was placed in the rabbit eye. (DuPont Company, 1947, 1963).
According to Regulation (EC) No. 1272/2008, 1,1,2,2 -tetrachloro-1,2-difluoroethane does not meet the classification criteria for Serious Eye Damage/Eye Irritation.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Reported data derive from the ACGIH sheet for the substance 1,1,2,2 -tetrachloro-1,2 -difluoroethane.
The American Conference of Governmental Industrial Hygienists(ACGIH) is a professional association of industrial hygienists and practitioners of related professions. One of the goals of the association is to provide information and guideline on exposure limits of substances in order to advance worker protection, and to this purpose the available scientific data on target substances are revised.
ACGIH summaries are based on a review of existing peer-reviewed scientific literature by committees of experts in public health and related sciences, therefore ACGIH is considered a reliable secondary source of information.
According to the ACGIH information, slight transient redness was seen in rabbits following application of 0.5 ml to the skin (DuPont Company, 1947, 1963) and mild irritation was seen when 1,1,2,2 -tetrachloro-1,2-difluoroethane was applied dermally to the skin of guinea pigs. (Clayton et al, 1966).
Furthermore, only slight and transient irritation was seen when 1,1,2,2-tetrachloro-1,2-difluoroethane was placed in the rabbit eye. (DuPont Company, 1947, 1963).
The reported slight signs of irritation are not sufficient to support the classification as Irritant both for Skin and Eye.
This conclusion on skin irritation is supported by the Acute dermal toxicity study in rabbits (test material administered undiluted, 4h).
Justification for selection of skin irritation / corrosion endpoint:
The reported reference is a secondary source which discusses the available literature data.
Justification for selection of eye irritation endpoint:
The reported reference is a secondary source which discusses the available literature data.
Justification for classification or non-classification
According to Regulation (EC) No. 1272/2008, 1,1,2,2 -tetrachloro-1,2-difluoroethane does not meet the classification criteria both for Skin Corrosion/Irritation and for Serious Eye Damage/Eye Irritation.
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