Registration Dossier
Registration Dossier
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EC number: 250-196-9 | CAS number: 30433-91-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Starting date: 7 November 1995
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: A study according to OECD guideline but not well documented nor GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 435 (In Vitro Membrane Barrier Test Method for Skin Corrosion)
- Principles of method if other than guideline:
- This method is based on the alteration of a dermal biobarrier. A chemical detection system (CTS) identifies the biobarrier destruction by detecting the chemical or physical changes. The reaction time is used to assign the proper packing group and classification
- GLP compliance:
- no
Test material
- Reference substance name:
- Thiophene-2-ethylamine
- EC Number:
- 250-196-9
- EC Name:
- Thiophene-2-ethylamine
- Cas Number:
- 30433-91-1
- Molecular formula:
- C6H9NS
- IUPAC Name:
- 2-(2-thienyl)ethanamine
- Reference substance name:
- 2-Thiopheneethanamine
- IUPAC Name:
- 2-Thiopheneethanamine
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): SR 26825 or 2-(2-thienyl) ethylamine
- Lot/batch No.: E/5228
- Control: 412106
Constituent 1
Constituent 2
Results and discussion
In vitro
Results
- Irritation / corrosion parameter:
- other: Reaction time
- Value:
- 37
- Remarks on result:
- positive indication of irritation
- Remarks:
- The means of the reaction times for the final step were 37 minutes and 20 second. The substance is classified as Corrosive Category 1 under GHS.
Any other information on results incl. tables
After categorization screen, the compound was defined as Category 1 material. The means of reaction times during the last step was 37 min 20 sec and the compound was classified as Corrosive Group II.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (corrosive) based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- SR 26825 [2-(2-thienyl) ethylamine], an intermediate compound of synthesis of SR25990C, was found corrosive in vitro. The compound was classified Corrosive Group II (USA), or 8/b (transport classification RTMDR) or R34 (EEC). He can be classified H314 in agreement with the Globally Harmonized Classification System (GHS).
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