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Short-term toxicity to aquatic invertebrates

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Description of key information

48h EC50 = 1.5 mg/L

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
1.5 mg/L

Additional information

Since no reliable short-term test is available for C8-18AS Mg & TEA (CAS 85586-38-5), in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5, a read-across to another structurally related category members was conducted. Read-across data from the following category members was used: C8AS Na (CAS 142-31-4), C10AS Na (CAS 142-87-0), C12AS Na (CAS 151-21-3), C14AS Na (CAS 1191-50-0), C16AS Na (CAS 1120-01-0), C12-18AS Na (CAS 68955-19-1). Toxicity of alkyl sulfates is dependent on the carbon chain length and the influence of the counter ion can be neglected. The test results with the C18 homologue (CAS 1120-04-3) were disregarded and are not presented. Since C18AS Na is insoluble in calcium-containing water (i.e., Ceriodaphnia test waters), the effects are due to physical interactions, not the classic uptake into the organism and then elicit toxicity.

One GLP short-term toxicity test with Daphnia magna performed according to OECD guideline 202 is available for C8AS Na (CAS 142-31-4; Neven 1993). Daphnids were exposed under semi-static conditions to five test concentrations up to 100 mg/L (nominal concentrations in agreement with the measured ones). Based on mobility of daphnids, the 48-hour EC50 value for C8AS Na (CAS 142-31-4) was determined to be above 100 mg/L (nominal concentration).

Two 24-hour tests with Daphnia magna are available for C10AS Na (CAS 142-87-0). The first non-GLP study was performed following an AFNOR T.90301 (1974) method (Lundahl and Cabridenc 1978). The obtained results showed that the 24-hour EC50 value was 800 mg/L (nominal concentrations). Analytical measurements are not available. The other non-GLP study with Daphnia magna followed a method described by Norme Francaise Homologue, 1983, NF T90-31 (Sanchez Leal 1991). The 24-hour EC50 value was 470 mg/L. Analytical check of the test concentrations was not provided. It is expected that the 48-hour EC50 value of C10AS Na (CAS 142-87-0) for aquatic invertebrates will be above 100 mg/L.

Moreover, a non-GLP test with Ceriodaphnia dubia is available for C12AS Na (CAS 151-21-3). Daphnids were exposed to six test concentrations of up to 101 mg/L (Lauth 1996a). The test was performed under flow-through conditions, no special guideline was followed. Mortality of daphnids was evaluated daily. The EC50 value determined for C12AS Na (CAS 151-21-3) after 48 hours of exposure was 5.55 mg/L.

Another non-GLP flow through test with Ceriodaphnia dubia is available for C14AS Na (CAS 1191-50-1; Lauth 1996b). The study was performed according to EPA-600/489/001 method. Ceriodapnia dubia was exposed to six concentrations up to 6.38 mg/L and mortality of daphnids was checked daily. The 48-hour LC50 value for C14AS Na (CAS 1191-50-1) was 1.58 mg/L.

The non-GLP 48-hour test with Ceriodaphnia dubia is available for C16AS Na (CAS 1120-01-0; Lauth 1996c). Daphnids were exposed under flow-through conditions to four test concentrations up to 0.38 mg/L and a control treatment. No special guideline was followed, no analytical measurements are available. The 48-hour LC50 value was 0.16 mg/L.

Moreover, a GLP test is available with C12-18AS Na (CAS 68955-19-1). The study was performed according to EU Method C.2 (Scholz 1997). Daphnids were exposed to five test concentrations up to 118 mg/L (measured value corresponding to 100 mg/L nominal concentration) for 48 hours under static conditions. The 48-hour EC50 value was determined based on mobility of daphnids as 15 mg/L (nominal concentration).

Due to structural and property similarities with the tested category members these results also can be used to determine the short-term toxicity to aquatic invertebrates of C8-18AS Mg & TEA (CAS 85586-38-5). For the calculation of a 48-hour EC50, short-term data available for the pure homologues C8AS Na (CAS 142-31-4), C10AS Na (CAS 142-87-0), C12AS Na (CAS 151-21-3), C14AS Na (CAS 1191-50-0) and C16AS Na (CAS 1120-01-0) were used. The composition of C8-18AS Mg & TEA (CAS 85586-38-5) based on the normalized mean values of provided ranges is C8: 15.8%, C10: 15.8%, C12: 44.7%, C14: 15.8%, C16: 5.3% and C18: 2.6%.

Using the additivity formula stipulated in EC Regulation 1272/2008, the 48-hour EC50 value of C8-18AS Mg & TEA (CAS 85586-38-5) for aquatic invertebrates is 1.5 mg/L.