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Physical & Chemical properties

Water solubility

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Description of key information

The water solubility of tetrairon tris(pyrophosphate) was determined according to EU Method A.6 (Water solubility) and under the conditions of GLP. 

Key value for chemical safety assessment

Water solubility:
0 g/L
at the temperature of:
20 °C

Additional information

The water solubility of the test material has been determined to be 3.67 x 10-4 g/l of solution at 20.0 ± 0.5°C.

The effect of temperature over the range 10 to 30°C has been considered not to have had a significant influence on the solubility of the test material (range 2.99 x 10-4 to 3.67 x 10-4 g/l).

The initial solution pH was shown to significantly influence solubility of the test material. When using an identical initial saturation period of 72 hours, the use of the pH 4 buffer solution significantly increased the resulting equivalent test material concentration dissolved (when compared to unbuffered water) to 0.297 g/l at 20.0 ± 0.5°C (at a final solution of 3.3), whereas the use of the pH 9 buffer solution decreased the resulting equivalent test material concentration to less than 2.52 x 10-4 g/l at 20.0 ± 0.5°C (at a final solution pH of 6.0). Therefore, although the maximum observed solubility was 0.297 g/l (at a final solution pH of 3.3), the water solubility of the test material may increase further in cases where additional buffering capacity exists.