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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Study not well documented. Only results available.

Data source

Reference
Reference Type:
secondary source
Title:
No information
Year:
1981
Bibliographic source:
Journal of Medicinal Chemistry. Vol. 24, Pg. 727, 1981 [RTECS]

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
α-(2,4-dichlorophenyl)-1H-imidazole-1-ethanol
EC Number:
246-042-5
EC Name:
α-(2,4-dichlorophenyl)-1H-imidazole-1-ethanol
Cas Number:
24155-42-8
Molecular formula:
C11H10Cl2N2O
IUPAC Name:
1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol

Test animals

Species:
mouse

Administration / exposure

Route of administration:
intraperitoneal

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
300 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Conclusions:
One part of the test substance administered intraperitoneal is rapidly absorbed from the peritoneum, another part of the substance experience a first pass-effect in the liver.
This mechanism caused that the intraperitoneal bioavailability of the test substance is greater than the oral, so based on the intraperitoneal LD50 = 300 mg/kg bw value, the substance can be classified into acute oral toxicity category 3.