Registration Dossier

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Study not well documented. Only results available.

Data source

Reference
Reference Type:
secondary source
Title:
No information
Year:
1981
Bibliographic source:
Journal of Medicinal Chemistry. Vol. 24, Pg. 727, 1981 [RTECS]

Materials and methods

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
mouse

Administration / exposure

Route of administration:
intraperitoneal

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
300 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Conclusions:
One part of the test substance administered intraperitoneal is rapidly absorbed from the peritoneum, another part of the substance experience a first pass-effect in the liver.
This mechanism caused that the intraperitoneal bioavailability of the test substance is greater than the oral, so based on the intraperitoneal LD50 = 300 mg/kg bw value, the substance can be classified into acute oral toxicity category 3.