Registration Dossier
Registration Dossier
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EC number: 939-725-0 | CAS number: -
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Referenced sources in an international report.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Dimethylformamide, SIDS Initial Assessment Report For SIAM 13
- Author:
- OECD
- Year:
- 2 001
- Bibliographic source:
- UNEP PUBLICATIONS
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No further details
- GLP compliance:
- no
Test material
- Reference substance name:
- N,N-dimethylformamide
- EC Number:
- 200-679-5
- EC Name:
- N,N-dimethylformamide
- Cas Number:
- 68-12-2
- Molecular formula:
- C3H7NO
- IUPAC Name:
- N,N-dimethylformamide
- Test material form:
- not specified
- Details on test material:
- N,N-Dimethylformamide, purity 99%, about 1 % (weight) Methanol, traces of Monomethylformamide and Formamide
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: Albino rabbits
Test system
- Vehicle:
- other: concentration: undiluted
- Controls:
- not specified
- Amount / concentration applied:
- Amount applied: about 50 μl (one drop)
- Duration of treatment / exposure:
- The substance was administered twice at an interval of 5 minutes into the eyes. The eyes were not rinsed.
- Observation period (in vivo):
- After 10 minutes, 1, 3 and 24 hours the eyes were examined and in case of findings, observation was continued until the findings disappeared.
- Number of animals or in vitro replicates:
- 2
Results and discussion
In vivo
- Irritant / corrosive response data:
- Marked redness and chemosis as well as purulent secretion were observed in both animals. In one animal transient opacity of the cornea occurred two days after substance application. Both animals recovered and were without findings 6 and 7 days after treatment, respectively.
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The DMF was found irritating to eyes.
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