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Short-term toxicity to aquatic invertebrates

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Description of key information

48h EC50 (Ceriodaphnia dubia, immobilization) = 5.55 mg/L (freshwater)
48h LC50 (Artemia salina, mortality) = 3.15 mg/L (nominal concentration, marine water)

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
5.55 mg/L
EC50/LC50 for marine water invertebrates:
3.15 mg/L

Additional information

Since no reliable short-term test involving aquatic invertebrates is available C12-isoAS Na (CAS 94200-74-5), in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 a read-across to another structurally related category member was conducted. Read-across data from another C12 homologue - C12AS Na (CAS 151-21-3) were used. As the toxicity of alkyl sulfates is dependent on the carbon chain length, it is expected that the toxic effects are comparable for all the C12 homologues and the influence of the counter ion can be neglected. In a non-GLP test Ceriodaphnia dubia was exposed to six test concentrations of CAS 151-21-3 up to 101 mg/L (Lauth 1996). The test was performed under flow-through conditions, no special guideline was followed. Mortality of daphnids was evaluated daily; the EC50 value determined after 48 hours of exposure was 5.55 mg/L. Furthermore, a non-GLP study with CAS 151-21-3 using a common marine species Artemia salina is available. In this static test mortality of Artemia was determined in culture dishes using six concentrations of test substance up to 18 mg/L (nominal concentrations). The LC50 value after 48 hours of exposure ranged between 3.15 and 3.8 mg/L (nominal concentration).

Due to structural and property similarities with the tested category member it can be concluded that the above result applies also to C12-isoAS Na (CAS 94200-74-5).