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Long-term toxicity to aquatic invertebrates

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Description of key information

The long-term toxicity to invertebrates of constituents of Alchisor TAL 145 has been documented within this dossier. Adequate reliable measured data exists for long-term toxicity to invertebrates to constituents of Alchisor TAL 145 (namely, Hydrocarbons C11-C14, n-alkanes, isoalkanes, cyclics, aromatics (2-25%), tetradecan-1-ol and dodecan-1-ol).  In a protective approach the most sensitive study result from across the three constituents has been identified and used to address the hazard endpoint in question. The most sensitive study result from across the three substances has been identified as a reliable study with tetradecab-1-ol (Schafers et al., 2009)  which reports an NOEC for long-term toxicity to aquatic invertebrates of 0.0016 mg/L. Consequently this value will be taken as the long-term toxicity to aquatic invertebrates endpoint for Alchisor TAL 145.

Key value for chemical safety assessment

EC10, LC10 or NOEC for freshwater invertebrates:
0.002 mg/L

Additional information

Alchisor TAL 145 can be characterised according to three constituents: Hydrocarbons C11-C14, n-alkanes, isoalkanes, cyclics, aromatics (2-25%), tetradecan-1 -ol and dodecan-1 -ol. Study data, where available, for each constituent has been evaluated and considered together. Several reliable (Klimisch 1 or 2) long-term toxicity studies in invertebrates have been conducted for constituents of Alchisor TAL 145 (namely, Hydrocarbons C11-C14, n-alkanes, isoalkanes, cyclics, aromatics (2-25%), tetradecan-1-ol and dodecan-1-ol) and are included in this dossier. The reliable studies included for constituents of Alchisor TAL 145 are briefly described below. In a protective approach, the most sensitive study result from across the three constituents will be identified and used to address the hazard endpoint in question.

 

Hydrocarbons C11-C14, n-alkanes, isoalkanes, cyclics, aromatics (2-25%)

Four reliable (Klimisch 1) long-term toxicity study results for invertebrates were available for Hydrocarbons C11-C14, n-alkanes, isoalkanes, cyclics, aromatics (2-25%) all which were provide by Exxon Biomedical Sciences, Inc (2005) GLP compliant OECD 211 study with Hydrocarbons C11-C14, n-alkanes, isoalkanes, cyclics, aromatics (2-25%) was conducted where Daphnia magna were exposed for 21 days to nominal loading concentrations of the test chemical. The EL10 based on reproduction was 0.316 mg/l. The EC10 based on reproduction was 0.109 mg/l. Reproduction was more sensitive than growth and survival, resulting in a NOELR of 0.28 mg/l and a NOEC of 0.097 mg/l.

 

Tetradecan-1-ol

One reliable (Klimisch 1) long-term toxicity study result for invertebrates was available for tetradecan-1-ol. Schafers et al., (2009) exposed D. magna to measured concentrations of tetradecan-1-ol for 21 days. A measured 21-day NOEC of 0.0016 mg/L based on reproduction was presented which is the most sensitive result for long-term toxicity of tetradecan-1-ol to invertebrates.

 

Dodecan-1-ol

Two reliable (Klimisch 1 or 2) long-term toxicity study result for invertebrates was available for dodecan-1-ol. Ghul (1992) conducted a reliable (Klimisch 2) GLP compliant study comparable to OECD guideline 202 by exposingD. magna for 21days with a resulting NOEC of 1 mg/L. Schaefers (2005) conducted a reliable (Klimisch 1) GLP compliant OECD 211 study where D. magna were exposed for 21 days. The NOEC, based on reproduction was 0.014 mg/L, which is the most sensitive long-term toxicity result for dodecan-1-ol.

 

The long-term toxicity to invertebrates of constituents of Alchisor TAL 145 has been documented within this dossier. Adequate reliable measured data exists for long-term toxicity to invertebrates to constituents of Alchisor TAL 145 (namely, Hydrocarbons C11-C14, n-alkanes, isoalkanes, cyclics, aromatics (2-25%), tetradecan-1-ol and dodecan-1-ol). In a protective approach the most sensitive study result from across the three constituent/constituent categories has been identified and used to address the hazard endpoint in question.The most sensitive study result from across the three substances has been identified as a reliable study with tetradecab-1-ol (Schafers et al., 2009) which reports an NOEC for long-term toxicity to aquatic invertebrates of 0.0016 mg/L. Consequently this value will be taken as the long-term toxicity to aquatic invertebrates endpoint for Alchisor TAL 145.