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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Hydrolysis

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Administrative data

Link to relevant study record(s)

Description of key information

Based on the results of a study performed using N,N-dimethyldecan-1-amide and on examination of the structure, the substance is not expected to hydrolyse to any significant extent.

Key value for chemical safety assessment

Half-life for hydrolysis:
462 d
at the temperature of:
25 °C

Additional information

No experimental data are available for the substance itself, however examination of the structure shows that the substance contains no hydrolysable groups. This is confirmed by a study performed on the read-across substance N,N-dimethyl decan-1-amide (CAS No. 14433 -76 -2). The objectives of the study according to EPA Guideline Subdivision N 161-1 (Hydrolysis) under GLP were to determine the rate of hydrolysis of the test substance and its degradation pattern in aqueous buffer solutions at target pH-values of 5, 7 and 9. Therefore, radiolabelled test substance was incubated at concentrations of 0.79 - 0.81 µg/ml in aqueous solutions under sterile conditions during 30 days at a temperature of 25 °C. The amounts of radioactivity were almost completely recovered. Balances within 30 days amounted, on average, to 96.5 ± 2.6 %, 95.1 ± 2.0 % and 93.8 ± 1.9 % of the radioactivity initially applied for pH 5, 7 and 9, respectively. Based on TLC- and HPLC-analyses, almost exclusively the parent compound was found at all time intervals and pH-values. During incubation, metabolite fractions M2 and M3 were detected in negligible amounts. Metabolite fraction M2 was found at all pH-values, ranging from 1.3 to 3.3 % of the radioactivity initially applied. Metabolite fraction M3 was only found at pH 5 and pH 7 (maximally 1.5 %). In conclusion, the test substance was hydrolysed to negligible extent at pH 5, 7 and pH 9 at 25 °C within 30 days.