Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-696-3 | CAS number: 98-73-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Although info about the batch of the tested substance is delivered, no info about its purity is given; statement that the study was performed in accordance with GLP guidelines but no provision of a certificate; info about the vehicle/application of the substance lacks some information details. The study was performed in accordance with an official guideline. The methodology, evaluation of the results and the results themselves are well documented.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: E.E.C. Directive 84/449/EEC appendix V B4
- GLP compliance:
- yes
Test material
- Reference substance name:
- 4-tert-butylbenzoic acid
- EC Number:
- 202-696-3
- EC Name:
- 4-tert-butylbenzoic acid
- Cas Number:
- 98-73-7
- Molecular formula:
- C11H14O2
- IUPAC Name:
- 4-tert-butylbenzoic acid
- Details on test material:
- - Name of test material (as cited in study report): ACIDE P-TERTIOBUTYLBENZOIQUE, Acide p.tertiobutylbenzoique (acide P.T.B.B.) lot 8802217
- supplier: Société Francaise Hoechst, Tour Roussel Hoechst, Cédex 03, 92080 Paris La Défense, France.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: "New-Zealand albino rabbits"
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Abbaye de Bellefontaine (49122 Bégrolles-en-Mauges, France)
- Sex: all males
- weight on day of treatment: 2.5 +/- 0.1 kg
- identification of individuals by ear-tags
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: clipped
- Controls:
- other: on each animal was a control site and a test site
- Duration of treatment / exposure:
- 4 h
- Observation period:
- up to 72 h
- Number of animals:
- 6
Results and discussion
Any other information on results incl. tables
Summary of results:
No cutaneous reaction was observed one hour, 24, 48 and 72 hours after the removal of the dressing. The scoring was at all times "0" concerning erythema and eschar formation as well as oedema formation.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: not specified
- Conclusions:
- According to the results of the study the test substance showed no cutaneous reactions (after 1, 24, 48 and 72 hours) on the rabbits skin and can therefore be considered as not irritating to the skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
