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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
18 Feb-15 Apr 2014
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Qualifier:
according to
Guideline:
EPA OPPTS 830.7950 (Vapor Pressure)
Principles of method if other than guideline:
The evaporation rate is calculated from the weight loss of the compound in the thermogravimetric analyser.
GLP compliance:
yes (incl. certificate)
Remarks:
GLP Compliance Monitoring Program, Health Care Inspectorate, Ministry of Health, Welfare and Sport, Den Haag, The Netherlands
Type of method:
other: isothermal thermogravimetric effusion method
Temp.:
20 °C
Vapour pressure:
<= 0.95 Pa
Remarks on result:
other: log P[Pa] <= -0.022
Temp.:
25 °C
Vapour pressure:
<= 1.6 Pa
Remarks on result:
other: log P[Pa] <= 0.19

Results of the isothermal TGA analysis:

Temperature [°C]

Weight loss [µg/min]

vT[g/cm2/h]

log vT

log P

P [Pa]

80

58.96

7.04E-03

-2.15

2.15

1.4E+02

64.71

7.72E-03

-2.11

2.19

1.6E+02

85

80.61

9.62E-03

-2.02

2.30

2.0E+02

85.37

1.02E-02

-1.99

2.33

2.1E+02

90

108.9

1.30E-02

-1.89

2.45

2.8E+02

114.1

1.36E-02

-1.87

2.47

3.0E+02

95

144.9

1.73E-02

-1.76

2.59

3.9E+02

151.8

1.81E-02

-1.74

2.62

4.1E+02

The equation of the pressure-temperature curve: log P[Pa] = -3777*1/T[K] + 12.86 (r = 0.995, n = 8).

The weight losses of the test substance were obtained with a temperature program which started above the melting temperature of the test substance. Due to the low melting point of the test substance this cannot be avoided. As a result, the vapour pressure of the test substance (which was, according to the method, extrapolated to 20 °C and 25 °C) could be slightly overestimated.

Description of key information

<= 0.95 Pa at 20 °C; <= 1.6 Pa at 25 °C (EU A.4, OECD 104, OPPTS 830.7950; isothermal TGA effusion method)

Key value for chemical safety assessment

Vapour pressure:
1.6 Pa
at the temperature of:
25 °C

Additional information

The weight losses of the test substance were obtained with a temperature program which started above the melting temperature of the test substance. Due to the low melting point of the test substance this could not be avoided. As a result, the vapour pressure of the test substance (which was, according to the method, extrapolated to 20 °C and 25 °C) could be slightly overestimated.