Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 207-236-5 | CAS number: 455-14-1
Endpoint summary
Administrative data
Description of key information
Available studies gave the following results:
p-TFMA is slightly irritating to the skin but not classified for this endpoint, and highly irritating to the eyes.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin irritation:
Only one study was available (Hazleton, 1985), with reliability 2 and was selected as key study. Its summary was the following:
In
a primary dermal irritation study (Hazleton, 1985), 6 rabbits were
dermally exposed to p-trifluoromethylaniline (>=98.5%) for 4 hours to
6.25 cm2 of dorsal/flank skin. Test site was covered with a
semi-occlusive patch for 4 hours. Animals then were observed 1, 24, 48
an 72 hours after removal the substance.
Irritation was scored following the erythema and oedema scale of EU
guideline.
The
mean value of erythema score was 0.44 without complete reversibility
after 72h. No oedema effects were observed.
In this study, p-trifluoromethylaniline (>=98.5%) is slightly irritating
but not a dermal irritant to the skin based on EU classification criteria
(67/548/EC diective ) and CLP criteria.
Eye irritation:
Only one study was available (Hazleton, 1985), with reliability 2 and was selected as key study. Its summary was the following:
In
a primary eye irritation study (Hazleton, 1985), 0.1 ml of undiluted
paratrifluoromethylaniline (>98.5) was instilled into the conjunctival
sac of one eye of 6 New Zealand White rabbits. Animals then were
observed for 3 days. Irritation
was scored by the method according
to criteria of directive EC 67/548.
After 72 hours, the overall irritation was Chemosis: 2.34; Conjonctiva:
1.5; Iris: 1; Cornea: 2, were not fully reversible within 72 h.
Based on this study, p-trifluoromethylaniline (>=98.5%) is considered
severely irritating to the eye and was classified XI R41 according to
the Annex VI of the directive 67/548/EC, and Eye damage Cat. 1 H318
according to the CLP criteria.
Effects on skin irritation/corrosion: slightly irritating
Effects on eye irritation: highly irritating
Justification for classification or non-classification
Based on results of these available studies, p-TFMA could be considered as not irritating to the skin and highly irritating to the eyes, according to the EC classification criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
