Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-696-3 | CAS number: 98-73-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- ACUTE ORAL TOXICITY OF P-TERT-BUTYLBENZOIC ACID IN RATS
- Year:
- 1 987
- Bibliographic source:
- Source: EPA/OTS
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-tert-butylbenzoic acid
- EC Number:
- 202-696-3
- EC Name:
- 4-tert-butylbenzoic acid
- Cas Number:
- 98-73-7
- Molecular formula:
- C11H14O2
- IUPAC Name:
- 4-tert-butylbenzoic acid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Acute oral toxicity was evaluated in groups of 10 female SPF Wistar rats administered single doses of P-tert-butylbenzoic acid using a probang (a flexible rod with a tuft or sponge at the end, used to apply to or remove matter from the esophagus or larynx)
Administration / exposure
- Route of administration:
- oral: gavage
- Doses:
- at levels of 400, 500, 630, 800, 1000, and 1600 mg/kg of body weight
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- ca. 642 mg/kg bw
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
