Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
other: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
1970
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1970
Report Date:
1970

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
The test item has been administered to rabbits at dose of 1000, 2000 and 4000 mg/kg bw.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder

Test animals

Species:
rabbit
Strain:
Vienna White
Sex:
male/female

Administration / exposure

Vehicle:
water
Duration of exposure:
24 hours
Doses:
1000, 2000 and 4000 mg/kg bw
No. of animals per sex per dose:
1000 mg/kg: 2 males and 1 female
2000 mg/kg: 2 females and 1 male
4000 mg/kg: 4 males and 2 females

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
3 000 mg/kg bw

Applicant's summary and conclusion

Interpretation of results:
other: not classified as harmful or toxic according to the CLP Regulation (EC) No.1272/2008
Conclusions:
LD50 for male/female rabbits is 3000 mg/kg.
Executive summary:

The toxicity of the substance via the dermal route was evaluated. The test item has been administered to male and female Vienna white rabbits at dose of 1000, 2000 and 4000 mg/kg bw.

LD50 for male/female rabbits was found as 3000 mg/kg.