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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Hydrolysis

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
hydrolysis
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
Data is from computational model developed by USEPA and secondary source
Qualifier:
according to guideline
Guideline:
other: Modeling database
Principles of method if other than guideline:
HYDROWIN Program (v2.00) from EPI Suite estimation database
GLP compliance:
not specified
Radiolabelling:
not specified
Analytical monitoring:
not specified
Estimation method (if used):
HYDROWIN v2.00
Positive controls:
not specified
Negative controls:
not specified
Transformation products:
not specified
Key result
Temp.:
25 °C
DT50:
> 1 yr
Type:
other: estimated data
Remarks on result:
other: Other details not known

HYDROWIN Program (v2.00) Results:

================================

SMILES : O=C(Nc(ccc(c1)CL)c1)Nc(ccc(c2CL)CL)c2

CHEM : Urea, N-(4-chlorophenyl)-N'-(3,4-dichlorophenyl)-

MOL FOR: C13 H9 CL3 N2 O1

MOL WT : 315.59

--------------------------- HYDROWIN v2.00 Results ---------------------------

Hydrolyzable Function detected: Urea (Normal)

R-N-C(=O)-N-R

(where R is an alkyl, aromatic carbon or hydrogen substituent(s))

These types of ureas hydrolyze slowly with half-lives generally > 1 year.

See the on-line User Guide help file for experimental rate data of

normal urea pesticides.

Validity criteria fulfilled:
not specified
Conclusions:
The estimated half-life of test chemical was evaluated to be > 1 yr (at 25ᵒC) respectively, indicating that it is not hydrolysable in water.
Executive summary:

HYDROWIN v2.00 program of Estimation Programs Interface (2018) prediction model was used to predict the hydrolysis half-life of test chemical. The estimated half-life of test chemical was evaluated to be > 1 yr (at 25ᵒC) respectively, indicating that it is not hydrolysable in water.

Description of key information

HYDROWIN v2.00 program of Estimation Programs Interface (2018) prediction model was used to predict the hydrolysis half-life of test chemical (Modelling database, 2018 and secondary source, 2002). The estimated half-life of test chemical was evaluated to be > 1 yr (at 25ᵒC) respectively, indicating that it is not hydrolysable in water.

Key value for chemical safety assessment

Half-life for hydrolysis:
1 yr
at the temperature of:
25 °C

Additional information

HYDROWIN v2.00 program of Estimation Programs Interface (2018) prediction model was used to predict the hydrolysis half-life of test chemical (Modelling database, 2018 and secondary source, 2002). The estimated half-life of test chemical was evaluated to be > 1 yr (at 25ᵒC) respectively, indicating that it is not hydrolysable in water.

Hydrolysis endpoint can also be considered for waiveras per in accordance with column 2 of Annex VIII of the REACH regulation, testing for this endpoint is scientifically not necessary and does not need to be conducted since the test chemical is readily biodegradable.