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EC number: 206-190-3 | CAS number: 306-83-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: High reliability because a scientifically defensible or guidelined method was used. Critical study for SIDS endpoint. Only study summary reviewed from secondary source.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Principles of method if other than guideline:
- The procedures used in the test were also based on the recommendations of EPA TSCA Guidelines 40 CFR 797.1300 (1989).
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2,2-dichloro-1,1,1-trifluoroethane
- EC Number:
- 206-190-3
- EC Name:
- 2,2-dichloro-1,1,1-trifluoroethane
- Cas Number:
- 306-83-2
- Molecular formula:
- C2HCl2F3
- IUPAC Name:
- 2,2-dichloro-1,1,1-trifluoroethane
- Reference substance name:
- Ethane, 2,2-dichloro-1,1,1-trifluoro-
- IUPAC Name:
- Ethane, 2,2-dichloro-1,1,1-trifluoro-
- Details on test material:
- - Name of test material (as cited in study report): HCFC-123
- Analytical purity: not reported.
- Name of test material (as cited in study report): HCFC 123
- Molecular formula (if other than submission substance): same as submission
- Molecular weight (if other than submission substance): same as submission
- Smiles notation (if other than submission substance): same as submission
- InChl (if other than submission substance): same as submission
- Structural formula attached as image file (if other than submission substance): same as submission
- Substance type: halogenated ethane
- Physical state: liquid
- Analytical purity: not reported
- Impurities (identity and concentrations): not reported
- Purity test date: not reported
- Lot/batch No.: BB305 D55A
- Expiration date of the lot/batch: not reported
- Stability under test conditions: stable
- Storage condition of test material: at room temperature in the dark
Constituent 1
Constituent 2
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: nominal concentrations 3.47, 6.94, 13.9, 27.7, 55.2 mg/l
At the start of the test a 2 ml sample was taken from each of the two additional bottles containing the freshly prepared test and control media. Samples were removed through a septum in the top of each bottle and were placed into sealed analytical vials. The sampling procedure was repeated at the study termination using 2 of the 4 test bottles at each level before they were opened for water quality measurements.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- The test media were made individually by dilution of aqueous stock solutions prepared in the test dilution water in a cold room (nominally 5ºC). Aqueous stock were shaken until all of the test material had disappeared before use. A control group was placed in dilution water alone.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: water flea
- Strain: not reported
- Source: University of Sheffield
- Age at study initiation (mean and range, SD): 6-24 hours old
- Weight at study initiation (mean and range, SD): not reported
- Length at study initiation (length definition, mean, range and SD): not reported
- Method of breeding: daphnia were fed 5 times/week with suspension of the alga C.vulgaris (from 2 x 10E5 to 8x10E5 cells/ml) and yeast (0.04 mg/l).
- Feeding during test: no
ACCLIMATION
- Acclimation period: no
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- 214 to 236 mg/L (as CaCO3)
- Test temperature:
- 20.6 ± 0.2ºC
- pH:
- 7.7-8.0
- Dissolved oxygen:
- 91-98% air saturation value
- Salinity:
- treated tap water
- Nominal and measured concentrations:
- nominal concentrations of 3.47, 6.94, 13.9, 27.7, and 55.2 mg/L
- Details on test conditions:
- The test vessels were all glass vials of approximately 120 mL capacity sealed with a rubber septum and a metal cap. Each test vessel was completely filled with water and 5 daphnia were added. The bottles were then sealed, with care being taken to ensure that there was no airspace. An aliquot of the appropriate stock was injected into each test vessel which were again fitted with a hypodermic needle to allow the excess water to be displaced. Four vessels, each containing 5 animals, were employed for each test and control group. Two additional vessels were also established at each concentration for use at the start of the test. Samples for chemical analysis and water quality measurements were taken from these bottles.
The day length was controlled, giving a photoperiod of 16 hours light and 8 hours darkness.
Alkalinity was 140-150 mg/L as CaCO3.
Measured levels of HCFC-123 in the aqueous stock solutions immediately after preparation ranged between 73 and 108% of their nominal values.
The temperature, pH, and concentration of dissolved oxygen of the dilution water and preparations of test substance at each exposure concentration were measured at the start and end of the test. The total hardness and alkalinity of the dilution water control were measured at the start and end of the test. Exposure levels were monitored by a GC method of analysis at the start of the test and at 48 hours. Observations of the daphnia were made after 24 and 48 hours of exposure.
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- < 2.24 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 17.3 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- 95% confidence interval, 13.6-23.1 mg/L (mean measured concentration).
At all concentrations, test media were clear and colorless. Results of duplicate samples at the beginning of the test indicated that achieved HCFC-123 concentrations were lower than intended (between 54 and 76% of their nominal values), but measured levels increased during the test (to between 119 and 141% of the starting concentrations after 48 hours). Measure concentrations are reported in table 1. The lowest HCFC-123 concentration employed (mean measured value 2.24 mg/L) resulted in 5% immobilization and the highest (mean measured value 44.0 mg/L) caused 100% immobilization after 48 hours. The 48-hour EC50 of HCFC-123 for immobilization, calculated using mean measured concentrations, was 17.3 mg/L. - Reported statistics and error estimates:
- The 24-hour values were approximations, obtained by nonlinear interpolation between nominal concentrations of 27.7 and 55.4 mg/L.
The 48-hour EC50 value was calculated by the moving average method.
Any other information on results incl. tables
Table 1 measured concentrations (mg/l)
|
Nominal concentrations (mg/l) |
|||||
Sampling |
0 |
3.47 |
6.94 |
13.9 |
27.7 |
55.2 |
0 h |
n.d. |
2.02 – 1.75 |
5.71 – 4.70 |
8.85 – 12.4 |
20.6 – 19.6 |
38.1 – 38.2 |
Mean (as % of nominal) |
- |
54 |
75 |
76 |
73 |
69 |
48 h |
n.d. |
2.60 – 2.59 |
6.75 – 6.78 |
11.8 – 13.5 |
27.0 – 29.5 |
49.6 – 49.9 |
Mean (as % of nominal) |
- |
75 |
97 |
91 |
102 |
90 |
Table 2 immobilised daphnia at 24 and 48 hours
|
Nominal concentrations (mg/l) |
|||||
|
0 |
3.47 |
6.94 |
13.9 |
27.7 |
55.2 |
24 h |
0/20 |
0/20 |
0/20 |
0/20 |
6/20 |
20/20 |
48 h |
1/20 |
1/20 |
2/20 |
3/20 |
10/20 |
20/20 |
Applicant's summary and conclusion
- Conclusions:
- The lowest HCFC-123 concentration employed (mean measured value 2.24 mg/L) resulted in 5% immobilization, and the highest (mean measured value 44.0 mg/L) caused 100% immobilization after 48 hours. The 24- and 48-hour EC50 of HCFC-123 for immobilization, calculated using mean measured concentrations, were 27.7 and 17.3 mg/L, respectively.
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