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EC number: 249-323-0 | CAS number: 28950-61-0
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 27 January 2014 to 06 February 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- no
- Type of method:
- flask method
- Specific details on test material used for the study:
- FAT 66042/Z TE
Lot. 0003340600 - Water solubility:
- 380 g/L
- Temp.:
- 20 °C
- Remarks on result:
- other: pH value is not available
- Conclusions:
- The water solubility of the test item at a temperature of 20 °C was 380 g/l.
- Executive summary:
The water solubility was performed according to OECD guideline 105 using flask method. Based on the study results, the water solubility cs of the test item at a temperature of 20 °C was (without correction for the purity) 380 g/l.
Reference
Preliminary visual estimation of the n-octanol solubility
Appearance of the test mixtures in the preliminary test
| Amount of test item in mg |
Total volume in ml |
Appearance of mixture |
| 100 | 1 | dissolved |
| 200 | 1 | dissolved |
The preliminary visual experiments showed that the water solubility of the test item is >200 g/l. Therefore the water solubility had to be determined by the “flask method”.
Flask-method
Water solubility of the test item – experiments A to D
| Experiment | A | B | C | D (Blank) |
| Amount of test item (mg) | 2.5 | 2.5 | 2.5 | / |
| Stirring time at 30 °C (h) | 24 | 48 | 72 | 72 |
| Aliquot of the flasks μl/10 ml | 5/0,01/100/3/10 | 5/0,01/100/3/10 | 5/0,01/100/3/10 | 5/0,01/100/3/10 |
| Measured concentration (μg/ml) | 9.5 | 11.1 | 11.4 | / |
| Water solubility (g/l) | 317 | 370 | 380 | / |
Concentrations of standards for recheck:
| Standard | Measured concentration (μg/ml) |
Recovery rate |
| Standard 1 (c = 0.92 μg/ml) | 0.91 | 98.9 % |
| Standard 2 (c = 2.30 μg/ml) | 2.32 | 100.9 % |
| Standard 4 (c = 9.20 μg/ml) | 9.22 | 100.2 % |
Recovery range from 98,9 % to 100,9 % indicates a sufficient accuracy of the analytical method.
Description of key information
The water solubility was performed according to OECD guideline 105 using flask method. Based on the study results, the water solubility cs of the test item at a temperature of 20 °C was (without correction for the purity) 380 g/l.
Key value for chemical safety assessment
- Water solubility:
- 380 g/L
- at the temperature of:
- 20 °C
Additional information
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