Registration Dossier
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EC number: 212-974-6 | CAS number: 894-86-0
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study according to internal BASF standards
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
- Principles of method if other than guideline:
- BASF Method
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Disodium [2,2'-bi-1H-indole]-3,3'-diolate
- EC Number:
- 212-974-6
- EC Name:
- Disodium [2,2'-bi-1H-indole]-3,3'-diolate
- Cas Number:
- 894-86-0
- Molecular formula:
- C16H12N2O2.2Na C16H10N2Na2O2
- IUPAC Name:
- disodium 1H,1'H-[2,2'-biindole]-3,3'-bis(olate)
- Details on test material:
- - Name of test material (as cited in study report): Indigoküpe BASF 60% Körner
- Substance type: preparation
- Physical state: solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- water
- Details on dermal exposure:
- 50% aqueous suspension
- Duration of exposure:
- no data
- Doses:
- 2500 mg/kg bw
- No. of animals per sex per dose:
- no data
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: -
- Necropsy of survivors performed: yes - Statistics:
- NA
Results and discussion
- Preliminary study:
- NA
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 500 mg/kg bw
- Mortality:
- no deaths
- Clinical signs:
- other: no effect
- Gross pathology:
- no effect
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- acute dermal LD50 in rats is higher than 2500 mg/kg bw
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