1,1'-binaphthyl-8,8'-dicarboxylic acid

Genetic toxicity: in vitro

Administrative data

Endpoint:

in vitro gene mutation study in bacteria

Remarks:

Type of genotoxicity: gene mutation

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP and Guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1984

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

other: Safepharm Standard Test Method M26

Test guideline 2

Qualifier:

equivalent or similar to guideline

Guideline:

other: Method of Ames et. al.

GLP compliance:

yes

Type of assay:

bacterial reverse mutation assay

Test material

Test material information

Constituent 1

Reference substance name:

1,1'-binaphthyl-8,8'-dicarboxylic acid

EC Number:

249-922-7

EC Name:

1,1'-binaphthyl-8,8'-dicarboxylic acid

Cas Number:

29878-91-9

Molecular formula:

C22H14O4

IUPAC Name:

[1,1'-binaphthalene]-8,8'-dicarboxylic acid

Method

Species / strain

Species / strain / cell type:

S. typhimurium TA 1535, TA 1537, TA 98 and TA 100

Metabolic activation:

with and without

Metabolic activation system:

S-9 Liver microson mix

Test concentrations with justification for top dose:

20-12,500 µg/plate

Vehicle / solvent:

DMSO

Results and discussion

Test results

Species / strain:

S. typhimurium TA 1535, TA 1537, TA 98 and TA 100

Metabolic activation:

with and without

Genotoxicity:

negative

Cytotoxicity / choice of top concentrations:

cytotoxicity

Remarks:

at dose levels of 2,500-12,500 µg/Plate toxicity was observed, resulting in a kill of the background lawn.

Vehicle controls validity:

valid

Remarks on result:

other: all strains/cell types tested

Remarks:

Migrated from field 'Test system'.

Applicant's summary and conclusion

Conclusions:

The test substance was found to be not mutagenic in the AMES-Test