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EC number: 219-110-7 | CAS number: 2362-14-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
- Absorption rate - oral (%):
- 50
- Absorption rate - dermal (%):
- 25
- Absorption rate - inhalation (%):
- 100
Additional information
No toxicokinetic studies are available that directly address absorption, distribution, metabolism, or excretion of Bis(3-methyl 4-hydroxyphenyl) cyclohexane (DMBPC, CAS# 2362-14-3) following oral administration; however information is available from existing toxicology studies and the physical chemical properties to infer potential toxicokinetic properties.
Absorption
The main physical chemical properties that influence absorption are molecular weight, and water and lipid solubility. DMBPC has a molecular weight of 294, a water solubility of 1.26 mg/L at 20 °C and Log Pow of 3.1. The substance contains two ionisable hydroxyl groups. Although ionized substances do not readily diffuse across biological membranes, the estimates of pKa values of DMBPC [ca. 10.5 (pKa 1) and ca. 10.7 (pKa 2)] indicate that the hydroxyl groups will not significantly be dissociated at biologically relevant pH values (up to pH 8). These properties suggest DMBPC would be absorbed by the gastro-intestinal tract following oral exposure although the limited water solubility will preclude complete systemic availability. The acute oral toxicity study showed low inherent systemic toxicity, and repeated oral toxicity studies revealed only non-specific systemic toxicity manifested as effects on body weight gain at the limit dose of 1000 mg/kg bw/day. In the absence of quantitative data oral absorption of DMBPC is considered moderate (50 %) for risk assessment purposes. Based on relatively high boiling point (336.2 °C) and extremely low vapour pressure (4.85x 10^-09 Pa at 25 °C) DMBPC is unlikely to volatilize or be released into the air. In addition, DMBPC is a solid with a mass median diameter of 35.9 µm and therefore it can be expected to reach just the thoracic tract of the respiratory system, but not the alveolar region. However, the low water solubility, the relatively low molecular weight and optimal Log Pow indicate inhalation as another possible route of absorption. It is likely that DMBPC will be absorbed if it is inhaled, based on available toxicity data showing a degree of bioavailability after oral exposure. As a worst-case assumption, inhalation absorption of DMBPC is considered high (100 %) for risk assessment purposes. Dermal absorption is likely to be moderate at most, because DMBPC is a solid, and will have to dissolve into the surface moisture of the skin before uptake can begin. The molecular weight is not excessive and the lipophilicity is appropriate for allowing the substance to cross the stratum corneum of the skin. However the low water solubility suggests that permeation through the stratum corneum into the epidermis would be low to moderate. In the absence of quantitative information and absence of effects in the acute dermal toxicity study, estimation of mammalian dermal absorption is made at 25 % in accordance with principles adopted by the EFSA guidance on estimating dermal absorption of pesticide active substances.
Distribution
Any DMBPC that is absorbed will be distributed via the blood to the liver and other organs and tissues because the molecular weight is not excessive.The moderate lipophilic character indicates that DMBPC is likely to distribute into cells and the intracellular concentration may be higher than extracellular concentration.
Metabolism and excretion
No specific target organ of toxicity has been identified in the repeated oral toxicity study, and the only possible indication of liver involvement in the metabolism of DMBPC in the OECD 422 study was a slight increase of alanine aminotransferase noted in females only treated at the limit dose of 1000 mg/kg bw/day. Phase I reactions including demethylation, hydroxylation and further oxidation are expected to occur, and Phase II reactions, including glucuronidation and sulfonation, will increase water solubility. Finally, based on the relatively low molecular weight, DMBPC and its conjugation products are expected to be mainly excreted in the urine. Overall, potential for bioaccumulation is considered low.
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