Registration Dossier
Registration Dossier
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EC number: 604-102-1 | CAS number: 13893-53-3
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
A 28-day repeated dermal neurotoxicity study was conducted to assess the potential of the test substance to cause systemic toxicity and adverse effects on the nervous system. The test substance was administered dermally to rats 5/sex/group) at concentrations of 0, 3, 10, and 30 mg/kg (0, 3.6, 11.9, and 35.8 µl/kg) for 6 hours/day, 5 days/week for 4 weeks. The test substance was applied by gentle inunction over the clipped area of unabraded skin. Dosages were adjusted at 3-day intervals to accommodate body weight changes. The treated area was covered with an impervious patch. After 6 hours, the patch was removed and the treated area thoroughly cleansed.
All rats survived the experimental period. No signs of systemic toxicity including neurotoxicity were observed in all dose groups. Skin irritation, consisting of mild erythema, eschar formation, dry and/or flaky skin, and small sores were observed at the application site of rats in the 10 and 30 mgkg dose groups. No significant irritation was seen in the rats in the 3 mg/kg dose group.
NOAEL (systemic effects) >= 30 mg/kg bw/d
NOAEL (local effects) 3 mg/kg bw/d
Justification for classification or non-classification
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