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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
abstract
Remarks:
citation in the IPCS "Concise International Chemical Assessment Document" 49

Data source

Reference
Reference Type:
publication
Title:
Thiouracils and Thioureas - Comparison of the Absorption, Distribution, Destruction and Excretion
Author:
Williams, R.H. and Kay, G.A.
Year:
1947
Bibliographic source:
Arch Intern Med. 80 (1); 37-52

Materials and methods

Objective of study:
absorption
Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
oral application of Thiourea with subsequent analysis of Thiourea content in urine and feces
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Thiourea
EC Number:
200-543-5
EC Name:
Thiourea
Cas Number:
62-56-6
Molecular formula:
CH4N2S
IUPAC Name:
thiourea
Test material form:
solid
Details on test material:
carbon atom in thiourea was radiolabelled
Radiolabelling:
yes

Test animals

Species:
other: human, rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Duration and frequency of treatment / exposure:
single exposure
Doses / concentrations
Remarks:
Doses / Concentrations:
a single oral dose of 28,57 mg Thiourea/kg bw (human)
5 mg administered intravenously (rat)
No. of animals per sex per dose / concentration:
no data

Results and discussion

Toxicokinetic / pharmacokinetic studies

Details on excretion:
A singel oral dose of 28,57 mg thiourea/kg bw in humans was completely eliminated within 48h in urine; a peak concentration was measured within 30 min.
In rats administered 5 mg intravenously, 30% of thiourea was recovered from the carcasses after 3h, and only traces after 25h.
No thiourea was excreted in the stools

Applicant's summary and conclusion

Conclusions:
Interpretation of results: no bioaccumulation potential based on study results
Thiourea is rapidly absorbed form the GI tract and completely eliminated in the urine.
Executive summary:

A singel oral dose of 28,57 mg thiourea/kg bw in humans was completely eliminated within 48h in urine; a peak concentration was measured within 30 min. In rats administered 5 mg intravenously, 30% of thiourea was recovered from the carcasses after 3h, and only traces after 25h. No thiourea was excreted in the stools.