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Diss Factsheets
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EC number: 200-543-5 | CAS number: 62-56-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- adult fish: sub(lethal) effects
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Reference
Description of key information
Based on the available results on short-term toxicity of thiourea to algae, daphnia and fish, as well as on the available long-term toxicity data on daphnia and subchronic toxicity data on fish, fish is expected to be the least sensitive species. Thus it is expected that additional long-term toxicity testing on fish according to OECD 210, 212, or 215 would not result in NOEC/EC10 values lower than the available NOEC values of 0.1 mg/L and 0.3 mg/L for invertebrates and algae, respectively. Therefore, additional long-term toxicity testing is deemed scientifically unjustified. Considering this and also due to animal welfare reasons a study proposal is not included in this dossier.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- NOEC
- Effect concentration:
- 5 000 mg/L
Additional information
Friesel et al. (1984) determined the sub-chronic toxicity (lethal and sublethal effects) of thiourea to the freshwater fish species Brachydanio rerio according to the German Guideline "Subletale toxische Wirkungen beim Zebrabärbling Brachydanio rerio (Schwellenniveau der letalen und anderer Wirkungen, NOEC, mindestens 14-Tage)" which is similar to the OECD Guideline 204 (Fish, Prolonged Toxicity Test: 14-day Study).
The 14 -d NOEC was found to be 5,000 mg/L. At 10,000 mg/L all animals were alive after 14 d exposure.
With regard to sublethal effects (swimming behaviour, morphology, feed intake, and reaction to external environmental stimuli) the LOEC was determined to be 7,000 mg/L.
Tests performed according to OECD 204 (Fish, Prolonged Toxicity Test: 14-Day Study (OECD 1984)) or similar guidelines cannot be considered as suitable long-term tests (see ECHA guidance R.7b, p. 25). They are, in effect, prolonged acute studies with fish mortality as the major endpoint examined.
However, the ECHA guidance further states (see p. 51) that in case suitable long-term toxicity data on fish according to OECD 215, 212, or 210 are not available, standard testing data might be substituted by a reliable non-standard study for fish. In addition, if there is evidence to suggest that fish are likely to be at least a factor of about 10 less sensitive than invertebrates or algae there are no further requirements for fish testing according to the ECHA guidance.
The test conducted by Friesel et al. (1984) was rated Klimisch III (not reliable) due to insufficient documentation of study design/set-up and results. However, this study was conducted in the context of a research project of the German Federal Environmental Agency (UBA). Thus, it is assumed that the test was conducted in an adequate and reliable manner. Therefore, the 14-d NOEC of 5000 mg/L for Brachydanio rerio is used to assess the relative sensitivity of fish compared to algae and daphnids:
The key values for freshwater invertebrates and algae that are used in the chemical safety assessment are NOEC = 0.1 mg/L and NOEC = 0.3 mg/L, respectively. Hence the NOEC for fish is ca. a factor 17,000 to 50,000 higher than the NOEC values for algae and daphnia, respectively and it can be stated with sufficient reliabilty that fish is the least sensitive species with regard to toxicity of thiourea. This finding is further supported by the available results on short-term toxicity of thiourea to daphnia, algae and fish.
Thus it is expected that additional long-term toxicity testing on fish according to OECD 210, 212, or 215 would not result in NOEC/EC10 values lower than the available NOEC values of 0.1 mg/L and 0.3 mg/L for invertebrates and algae, respectively. Therefore, additional long-term toxicity testing is deemed scientifically unjustified. Considering this and also for animal welfare reasons a study proposal is not included in this dossier.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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