Registration Dossier
Registration Dossier
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EC number: 619-535-1 | CAS number: 68418-51-9
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Older study by a recognised laboratory.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Type of study:
- not specified
Test material
- Reference substance name:
- Bis(4-fluorophenyl) ketone
- EC Number:
- 206-466-3
- EC Name:
- Bis(4-fluorophenyl) ketone
- Cas Number:
- 345-92-6
- IUPAC Name:
- bis(4-fluorophenyl)methanone
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- other: SPF-derived, albino strain
- Sex:
- not specified
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- epicutaneous, occlusive
- Vehicle:
- other: dimethyl formamide
- Concentration / amount:
- 10%, 1% and 0.1%
Challengeopen allclose all
- Route:
- epicutaneous, occlusive
- Vehicle:
- other: dimethyl formamide
- Concentration / amount:
- 10%, 1% and 0.1%
- Positive control substance(s):
- not specified
Results and discussion
- Positive control results:
- No erythematous reactions were observed in either test or control animals.
In vivo (non-LLNA)
Results
- Reading:
- other:
- Hours after challenge:
- 336
- Group:
- other:
- Dose level:
- 1000mg/kg
- No. with + reactions:
- 0
- Total no. in group:
- 3
- Remarks on result:
- other: Reading: other:. . Hours after challenge: 336.0. Group: other:. Dose level: 1000mg/kg. No with. + reactions: 0.0. Total no. in groups: 3.0.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
- Executive summary:
Read across from bis(4 -fluorphenyl)ketone as it is analogous with 1,4'-bis(4-fluorobenzoyl)benzene in that it has:
equal number of chain ending identical inorganic groups.
structure with similar chain extending properties.
similar aquesous solubility properties
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