Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 266-417-7 | CAS number: 66587-56-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1984
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Research publication, study well documented, meets generally accepted scientific principles, acceptable for assessment. The liver was the only organ examined microscopically.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 984
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Research study to investigate effects on peroxisome perliferation in the rat using only one concentration of the test material which was given by gavage for 14 days. Only the liver was examined microscopically at study termination.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Alcohols, C6-12
- EC Number:
- 271-642-9
- EC Name:
- Alcohols, C6-12
- Cas Number:
- 68603-15-6
- IUPAC Name:
- octan-1-ol
- Details on test material:
- - Name of test material (as cited in study report): Linevol 79, C6-12 alcohols Type C
- Substance type: technical product
- Physical state: liquid
- Analytical purity: no data
- Impurities (identity and concentrations): no data
- Composition of test material, percentage of components: mainly C7-C9 alcohols
- Isomers composition: no data
- Purity test date: no data
- Lot/batch No.: no data
- Expiration date of the lot/batch: no data
- Stability under test conditions: no data
- Storage condition of test material: no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: ICI
- Age at study initiation: no data
- Weight at study initiation: no data
- Fasting period before study: no data
- Housing: individually in steel, screen-bottomed cages
- Diet (e.g. ad libitum): conventional, ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data
IN-LIFE DATES: no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- polyethylene glycol
- Details on oral exposure:
- PREPARATION OF DOSING SOLUTIONS: test material dissolved in polyethylene glycol 300
VEHICLE
- Justification for use and choice of vehicle (if other than water): no data
- Concentration in vehicle: 12.8 mg/ml
- Amount of vehicle (if gavage): 10 ml/kg bw/day - Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 14 days
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
1 mmol/kg bw/day (128 mg/kg bw/day)
Basis:
actual ingested
- No. of animals per sex per dose:
- 5 males - treatment group
10 males - control group - Control animals:
- yes, concurrent vehicle
- Positive control:
- Diethylhexylphthalate (DEHP)
Examinations
- Observations and examinations performed and frequency:
- CAGE SIDE OBSERVATIONS: Yes
- Time schedule: daily
DETAILED CLINICAL OBSERVATIONS: No data
BODY WEIGHT: Yes
- Time schedule for examinations: no data, but at least weighed pre-dosing and at study termination
FOOD EFFICIENCY:
- Body weight gain in kg/food consumption in kg per unit time X 100 calculated as time-weighted averages from the consumption and body weight gain data: No data
OPHTHALMOSCOPIC EXAMINATION: No
HAEMATOLOGY: No
CLINICAL CHEMISTRY: Yes
- Time schedule for collection of blood: at study termination
- Animals fasted: No data
- How many animals: 5 treated group; 10 control group
- Parameters examined: plasma cholesterol and plasma tryglycerides
URINALYSIS: No
NEUROBEHAVIOURAL EXAMINATION: No
OTHER: liver homogenised and 15000 X g fraction prepared for enzyme assays for total catalase and cyanide (CN)-insensitive palmitoyl CoA oxidation - Sacrifice and pathology:
- GROSS PATHOLOGY: No data
HISTOPATHOLOGY: Yes; only the liver was microscopically examined - Other examinations:
- weights of liver and testis
- Statistics:
- none
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Mortality:
- no mortality observed
- Body weight and weight changes:
- no effects observed
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- no effects observed
- Urinalysis findings:
- not examined
- Behaviour (functional findings):
- not examined
- Organ weight findings including organ / body weight ratios:
- no effects observed
- Description (incidence and severity):
- testis and liver only were weighed
- Gross pathological findings:
- no effects observed
- Histopathological findings: non-neoplastic:
- no effects observed
- Histopathological findings: neoplastic:
- not examined
- Details on results:
- CLINICAL SIGNS AND MORTALITY
No deaths occurred during the study and no clinical signs of toxicity were reported
BODY WEIGHT AND WEIGHT GAIN
Body weight gain was similar in the treated and control groups
FOOD CONSUMPTION AND COMPOUND INTAKE (if feeding study)
No differences in food consuption were reported
FOOD EFFICIENCY
No differences in food efficiency were reported
CLINICAL CHEMISTRY
Levels of plasma and triglycerides were comparable in the treated and control groups
ORGAN WEIGHTS
Liver:bw ratio and testis:bw ratio were similar in the treated and control animals
[It is usual to evaluate absolute testis weight, rather than relative weight; absolute organ weights not reported.]
GROSS PATHOLOGY
No macroscopic findings were reported
HISTOPATHOLOGY: NON-NEOPLASTIC
Minor histological changes, seen as slight centrilobular hypertrophy and "fat" type vacuolation of the liver were evident in both treated and control animals
OTHER FINDINGS
The test substance had no effect on the enzyme catalase or on peroxisome perliferation
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 128 mg/kg bw/day (actual dose received)
- Based on:
- test mat.
- Sex:
- male
- Basis for effect level:
- other: only one dose level tested; no effect on a limited range of endpoints (testis or liver weights (relative to body weight), peroxisome proliferation, hepatomegaly or hypolipidaemia)
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
In vivo studies: There were no effects on relative testes weight, relative liver weight showed a slight* significant increase with 3,5,7-trimethyl hexanol. The postive control DEHP showed a clearly significant increase** in relative liver weight. There were no significant changes in testes weight relative to controls. Histopathological examination of the liver revealed no treatment related changes. Only the positive control DEHP showed any peroxisome proliferation or effects on cholesterol or triglycerides and catalase was unaffected by treatment.
In vitro levels of palmitoyl CoA oxidase were increased only in the positive control group (MEHP).
None of the alkanols investigated at dose levels of 1 mmol/kg bw showed any evidence of peroxisome proliferation, hepatomegaly, or hypolipidaemia.
Applicant's summary and conclusion
- Conclusions:
- In a reliable study, conducted to determine the effects of Linevol 79 (C6-12 alcohols Type C) on the testis and the histology and peroxisome activity in the liver, 128 mg/kg bw/day given to male rats daily for 14 days had no effects on testis or liver weights, peroxisome proliferation, hepatomegaly or hypolipidaemia. For the limited range of endpoints evaluated, an NOAEL of 128 mg/kg bw/day was identified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.