Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 485-280-6 | CAS number: 303749-96-4
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on developmental toxicity
Description of key information
The pre-natal developmental toxicity of 1 -H-Tetrazol-5-amine-,N-1 H-tetrazol-5- yl-,monoammonium salt was investigated according to US-EPA Guideline OPPTS 870.3700.
The maternal No-Observable-Adverse-Effect Level (NOAEL) and the No-Observable-Effect Level (NOEL) for developmental toxicity in this developmental toxicity study in rats with 1 -H-Tetrazol-5amine-,N-1 H-tetrazol-5- yl-,monoammonium salt was 200 mg/kg/day.
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- NOAEL
- 200 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
- Quality of whole database:
- One reliable GLP-study is available.
Additional information
Reliable without restrictions
Justification for classification or non-classification
Developmental toxicity was manifested when given at a dosage which indicate clearly recognizable general maternal toxicity.Therefore, classification of 1 -H-Tetrazol-5amine-,N-1 H-tetrazol-5-yl-,monoammoniumsalt for developmental toxicity based on non-maternal mediated pup toxicity is not justified.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
