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Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

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Description of key information

No toxic effects to aquatic algae up to the limit of water solubility (< 0.05 mg/L).

Key value for chemical safety assessment

Additional information

In accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 a read across to a structurally related category memberfatty acids, C16-18 and C18-unsatd., tetraesters with pentaerythritol(CAS 68604-44-4) was conductedto fulfill the data requirements according to Annex VII-IX of 2,2-bis(hydroxymethyl)-1,3-propanediyl dioleate (CAS 25151-96-6) in regard to toxicity to aquatic algae and cyanobacteria. This read-across is justified in detail in the overall summary (IUCLID chapter 6.1) and within the category justification in IUCLID Section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substances were used for the assessment. The target as well as the read-across substance both contain longer fatty acid chains (C18) and pentaerythritol as alcohol.

A limit test with the read-across substancefatty acids, C16-18 and C18-unsatd., tetraesters with pentaerythritol(CAS 68604-44-4) was performed according to OECD 201 (Junghans, 2010). The green algae Desmodesmus subspicatus was exposed to a nominal concentration of 100 mg/L. The WAF was prepared by adding the appropriate amount of test substance with subsequent stirring followed by filtration. No effect on growth rate and biomass of Desmodesmus subspicatus up to the limit of water solubility was observed resulting in an EL50 > 100 mg/L (nominal) and a NOELR of ≥ 1000 mg/L (nominal).

Based on this result from a structurally related read-across substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which is characterized by a similar ecotoxicological profile, it can be concluded that2,2-bis(hydroxymethyl)-1,3-propanediyl dioleate (CAS 25151-96-6)will not exhibit effects to aquatic algae up to the limit of water solubility.As it can be seen in the data matrix of the category justification in section 13 and the overall endpoint summary IUCLID 6.1, all reliable data in the polyol esters category support this hazard assessment by showing a consistent pattern of results, i.e no toxic effects were observed to aquatic algae or other aquatic organisms up to the limit of water solubility.

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