Registration Dossier
Registration Dossier
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EC number: 202-485-6 | CAS number: 96-17-3
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Studies on major metabolic pathways of 2-methylbutanal could not be identified. But it is assumed that the metabolism is similar to other aldehydes. In general, aldehydes are primarily oxidized to the corresponding carboxylic acid. Subsequently, they follow the metabolic pathways of this carboxylic acid.
In the study located (Roberts 1991), the deformylation reaction resulting in olefin formation of C3 to C5 aldehydes was investigated using a reconstituted system of different cytochrom P-450 isozymes. This reaction is not a major metabolic pathway of 2-methylbutyraldehyde.
In order to achieve deformylation and formation of the corresponding olefin, branching at theα-carbon atom was required. Activity increased with increasing branching (trimethylacetaldehyde > 2-methylbutyraldehyde > butyraldehyde).
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