Registration Dossier
Registration Dossier
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EC number: 273-258-7 | CAS number: 68955-20-4 This substance is identified by SDA Substance Name: C16-C18 alkyl alcohol sulfuric acid sodium salt and SDA Reporting Number: 19-062-04.
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment Adopted according to OECD SIDS or other official EU regulation procedures (public available peer reviewed source).
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Reference Type:
- secondary source
- Title:
- SIDS Category of Alkyl sulfates, Alkane sulfonates and Alpha-olefin sulfonates
- Author:
- OECD
- Year:
- 2 007
- Bibliographic source:
- UNEP Publications
Materials and methods
- Principles of method if other than guideline:
- Method: other: P&G standard procedure #1
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 68955-19-1 (purity 25%)
- IUPAC Name:
- 68955-19-1 (purity 25%)
- Details on test material:
- - Name of test material (as cited in study report): No data
- Physical state: No data
- Analytical purity: 25% a.i.
- Lot/batch No.: No data
- Storage condition of test material: No data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Cox CD
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 2500, 3500, 4900 and 6850 mg/kg bw
- No. of animals per sex per dose:
- 10
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 4 010 mg/kg bw
- Based on:
- act. ingr.
Any other information on results incl. tables
LD50 (confidence limits): 3390 - 4740 mg/kg
MORTALITY
-Time of death: all deaths occurred within 24 hrs to 7 days after dosing
-Number of deaths at each dose:
2500 mg/kg: 0/10
3500 mg/kg: 5/10
4900 mg/kg: 6/10
6850 mg/kg: 10/10
CLINICAL SIGNS
>= 2500 mg/kg: slight to moderate decreased motor activity and respiratory
rate, blanching, abdominal griping and diarrhoea
>= 3500 mg/kg: slight degrees of haemorrhagic rhinitis; persistent
symptoms and delayed deaths were noted up to seven days post-treatment
6850 mg/kg: slight loss of corneal reflex and pupilary responses
NECROPSY FINDINGS
necropsy of survivors: no abnormalities
POTENTIAL TARGET ORGANS
-none
SEX-SPECIFIC DIFFERENCES
-none
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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