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EC number: 265-188-0 | CAS number: 64742-85-4 A complex combination of hydrocarbons obtained by treating a vacuum residuum with hydrogen in the presence of a catalyst under conditions primarily to remove organic sulfur compounds. It consists of hydrocarbons having carbon numbers predominantly greater than C34 and boiling approximately above 495°C (923°F).
In an acute dermal toxicity study, groups of New Zealand White Rabbits (4/sex) were dermally exposed to Vacuum Residuum (petroleum) for 24 hours to 10% of body area at a single dose of 2000 mg/kg body weight. Skin was abraded in 2 male and 2 female animals before application. Animals then were observed for 14 days.
There were minimal treatment related clinical signs and no significant treatment related necropsy findings or changes in body weight. The dermal LD50 was determined to be greater than 2000 mg/kg body weight in in males and females.
This study received a Klimisch score of 1 and is classified as reliable without restriction because it was carried out in a method similar to OECD TG 402.
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