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EC number: 225-730-9 | CAS number: 5036-48-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- October 1985 - January 1986
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not applicable
- Principles of method if other than guideline:
- The study was performed prior to the implementation of OECD Guidelines, but is in compliance with the principles described in OECD Guideline 401.
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- 1H-imidazole-1-propylamine
- EC Number:
- 225-730-9
- EC Name:
- 1H-imidazole-1-propylamine
- Cas Number:
- 5036-48-6
- Molecular formula:
- C6H11N3
- IUPAC Name:
- 3-(1H-imidazol-1-yl)propan-1-amine
- Details on test material:
- - Name of test material (as cited in study report):N-(3-Aminopropyl)-Imidazol
- Physical state: liquid
- Analytical purity: 99.7 %
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dr. K. Thomae GmbH, Bieberach
- Housing: 5 animals per cage
- Fasting period before study: 16 h, water available ad libitum
- Diet (e.g. ad libitum): ad libitum (Liba-Labordiaet)
- Water (e.g. ad libitum): adlibitum, tap water
- Acclimation period: at least 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 - 24 C°
- Humidity (%): 30 - 70 %
- Photoperiod (hrs dark / hrs light): 12 h / 12 h
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 3160, 2150, 1470, 1000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 780 mg/kg bw
- Mortality:
- Yes, see tables
- Clinical signs:
- other: Apathy, abnormal position, staggering, paresis, spastic gait, piloerection, diarrhea, poor general state
- Gross pathology:
- Animals that died:
General congestive hyperemia
Stomach: atonic, dark red with bloody contents (gastritis by corrosion)
Small and large intestines: dark red, bloody contents
Sacrifieced animals:
1 male animal slight intraabdominal adhesions. Organs of the remaining aniumals: no abnormalities detected
Any other information on results incl. tables
Mortality:
|
1 h |
24 h |
48 h |
7 d |
14 d |
|||||
Dose (mg/kg) |
male |
female |
male |
female |
male |
female |
male |
female |
male |
female |
3160 |
0 |
0 |
4 |
5 |
5 |
5 |
5 |
5 |
5 |
5 |
2150 |
0 |
0 |
3 |
5 |
3 |
5 |
3 |
5 |
3 |
5 |
1470 |
0 |
0 |
1 |
0 |
1 |
0 |
1 |
1 |
1 |
1 |
1000 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Executive summary:
The study was performed comparable to OECD 401 with acceptable restrictions. Groups of 10 rats per dose were administered with 1000, 1470, 2150, and 3160 mg/kg bw. The acute LD50 was 1780 mg/kg in rats. Observed linical signs were apathy, abnormal position, staggering, paresis, spastic gait, piloerection, diarrhea, poor general state (1985, RL2).
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