Registration Dossier
Registration Dossier
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EC number: 267-291-6 | CAS number: 67828-72-2
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: OECD Guideline 105 and ETAD method
- Principles of method if other than guideline:
- To measure the partition coefficient of pigments utilising the standard OECD Guideline 107 is extremely difficult because of the problems associated with the inherent very low solubilities. The following procedure is used for determining the LogPow of low solubility substances and in particular that of pigments.
The partition coefficient was estimated based on the ratio of the solubilities in n-octanol and in water. The individual solubilities were determined by flask method based on OECD Guideline 105 and the ETAD method. - GLP compliance:
- no
- Type of method:
- estimation method (solubility ratio)
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Pigment Rot 52:Sr
- Physical state: powder
- Lot/batch No.: JW111201 - Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 1.22
- Temp.:
- 23 °C
- Remarks on result:
- other: pH was not reported
Reference
The concentration of the pigment in water and in n-octanol was determined by HPLC-UV
Average concentration of 3 tests:
Cn-octanol= 197µg/L
Cwater= <15µg/L
The n-octanol/water partition coefficient can be approximated with the following equation:
Pow= (Cn-octanol/ Cwater)= 16.7
logPow= 1.22
Description of key information
Estimated based on solubility ratio:
log Pow = 1.22 at 23°C
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 1.22
- at the temperature of:
- 23 °C
Additional information
The partition coefficient was estimated based on the ratio of the solubilities in n-octanol and in water.
The individual solubilities were determined by flask method based on OECD Guideline 105 and the ETAD method. The quantification was analyzed by UV/Vis absorption.
The non-resin-coated test substance is representative pure substance therefore its data has been chosen as the key study.
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