Pentan-2-one

Melting point / freezing point

Link to relevant study record(s)

Reference

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

May 2013

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Deviations:

no

GLP compliance:

no

Type of method:

thermal analysis

Remarks:

ASTM D3418

Remarks on result:

other: MPK, no melting can be found, even cooled @.1°C/min. No Tg can be found in this temperature range between -80°C and 25°C.

*INFORMATION REQUIREMENTS-Corresponds to solid/liquid phase change at atmospheric pressure. Study does not need to be conducted below a lower limit of -20 °C.

 

METHOD

 

The melting point was determined using a TA Instruments Q2000 DSC equipped with a Liquid Nitrogen Cooling System with a Heat-Cool-Heat method which conforms to ASTM D3418.

 

PROCEDURE

 

DSC is calibrated @ 10°C/min. with Alfa Aesar’s Adamantane, 98%, Stock #A14041, CAS#281-23-2, for onset of melting @ -65.54°C +/-0.4°C and NIST’s Indium for onset of melting @ 156.60°C +/- 0.4°C and constant for Heat of Fusion of 6.8 cal/g. The instrument is purged with Helium @ 50 c.c./min. and scanning rates for heating is 10°C/min. and cooling rates are 0.1.  Sample was encapsulated in TA’s Tzero Aluminum pan and Tzero hermetic Aluminum lid. For liquid samples, the temperature range was from -80°C to 25°C. For others, the temperature range was from -50°C to 200°C or 220°C.

 

CALCULATIONS

 

Due to the unknown heat history of the sample, only the 2^ndheating scan was used for the calculation. The onset of melting peak temperature, T_onset, and melting peak temperature,

T_m, as well as onset of Tg were analyzed using TA Instruments Universal Software V4.7A. 

 

RESULTS/CONCLUSION

 

For LIMS#483977: MPK, no melting can be found, even cooled @.1°C/min. No Tg can be found

                                            in this temperature range between -80°C and 25°C.

 

Conclusions:

MPK, no melting can be found, even cooled @.1°C/min. No Tg can be found in this temperature range between -80°C and 25°C

Executive summary:

MPK, no melting can be found, even cooled @.1°C/min. No Tg can be found in this temperature range between -80°C and 25°C

Description of key information

MPK, no melting can be found, even cooled @.1°C/min.  No Tg can be found in this temperature range between -80°C  and 25°C.