Registration Dossier
Registration Dossier
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EC number: 939-523-2 | CAS number: 1471312-55-6
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The chemical safety assessment carried out according to Annex I of Regulation (EC) No 1907/2006 does not indicate the need to investigate further the long-term toxicity to fish.
Key value for chemical safety assessment
Additional information
There are no long-term fish studies available for AES (C8-10, 1-2.5EO) Na. Based on the available acute and chronic toxicity data of alkyl ether sulfates, fish cannot be identified as the most sensitive taxonomic group. According to the “Guidance on information requirements and chemical safety assessment Chapter R.7b: Endpoint specific guidance, R.7.8.5.3” (ECHA, 2008), long-term testing of fish should only be conducted if it represents the most sensitive taxonomic group. The Guidance Document states that if invertebrates are likely to be more sensitive than fish and algae or the relative sensitivity of invertebrates cannot be predicted, long-term testing on Daphnia sp. should be preferred instead of fish.
The results of a chronic invertebrates study carried out with Daphnia magna show an NOEC of 5.3 mg a.i./L. Since for the AES (C12-14, 1-2.5EO) the chronic results of fish and daphnids are in the same range, it can be assumed that for the AES (C8-10, 1-2.5EO) the results of a long-term fish study will not be significantly different from the results of the available chronic Daphnia study. Hence, based on the information discussed above and due to animal welfare reasons, no further long-term test with fish is proposed.
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