Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2013
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: testing method performed according to OECD107

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2013
Report date:
2013

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Type of method:
shake-flask method to: flask method
Partition coefficient type:
octanol-water

Test material

Constituent 1
Chemical structure
Reference substance name:
4'-chloro-3-hydroxy-2-naphthanilide
EC Number:
202-189-7
EC Name:
4'-chloro-3-hydroxy-2-naphthanilide
Cas Number:
92-78-4
Molecular formula:
C17H12ClNO2
IUPAC Name:
N-(4-chlorophenyl)-3-hydroxynaphthalene-2-carboxamide

Study design

Analytical method:
photometric method

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
2.97
Temp.:
23 °C
pH:
ca. 7.2

Any other information on results incl. tables

Table 1: Results in detail

   determ. no.

    stock solution [ml]  n-octanol [ml]     test substance conc. in n-octanol phase [mg/l]   test substance conc. in water phase [mg/l]   log Pow   
  A1 5 10 755,9  0,58  3,1 
  A2  5   10  759,4  0,57  3,1 
  B1  10 10 748,7  0,73  3,0 
  B2  10  10 756,9 0,83  3,0 
  C1  20   10  750,9  3,49  (2,3)* 
  C2  20  10 752,7  1,77  2,6 

mean

 ---   ---   ---   ---  2,97 

*: outlier, not considered

Stock solution: 750 mg/l

Applicant's summary and conclusion

Conclusions:
Due to the partition coefficient n-octanol-water bioaccumulation is not expected.