Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 212-769-1 | CAS number: 868-14-4
Respiratory sensitisation
Administrative data
- Endpoint:
- respiratory sensitisation
- Remarks:
- other: medical monitoring
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study has been assessed for the use in a category approach. According to the methodology and to the extent of available details, the study has been judged as reliable with restrictions.
Data source
Reference
- Reference Type:
- publication
- Title:
- Indagine su un gruppo di soggetti con esposizione professionale ad acido tartarico
- Author:
- Moscato et al.
- Year:
- 1 983
- Bibliographic source:
- ltal. Med. Lav. 1983; 5: 193-198.
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Evaluation of human workers occupationally-exposed to tartaric acid.
The study reports the results of un investigation carried out in a factory producing tartaric acid in order to evaluate the effects of occupational exposure to tartaric acid. A group of 74 subjects exposed to the acid and a group of 30 subjects not exposed, as a means of control, were submitted to unamnestic questionnaire. - GLP compliance:
- not specified
Test material
- Reference substance name:
- (+)-tartaric acid
- EC Number:
- 201-766-0
- EC Name:
- (+)-tartaric acid
- Cas Number:
- 87-69-4
- Molecular formula:
- C4H6O6
- IUPAC Name:
- (2R,3R)-2,3-dihydroxybutanedioic acid
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- No further details on the test material identity are available.
Constituent 1
Test animals
- Species:
- human
- Strain:
- other: not applicable
- Sex:
- not specified
Test system
- Route of induction exposure:
- other:
- Route of challenge exposure:
- inhalation
- Vehicle:
- not specified
- Concentration:
- no data
- No. of animals per dose:
- Selection of the subjects:
- 74 workers
44 subjects belonging to risk group, assigned the production of tartaric acid.
30 subjects belonging to the control group (not exposed to tartaric acid)
- history evaluated for each subject: occupational, family, medical - Details on study design:
- no data
- Challenge controls:
- no data
- Positive control substance(s):
- not specified
- Negative control substance(s):
- other: not exposed subjects
Results and discussion
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
