Registration Dossier
Registration Dossier
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EC number: 221-259-8 | CAS number: 3048-64-4
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
48 hr EC50 in Daphnia magna: 7.3 mg/L. QSAR estimate 2.48mg/l
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 7.3 mg/L
Additional information
In a guideline (OECD 202) and GLP study, LISEC (1999) reported a 48 -hr EC50 value of 7.3 mg/L (95% C.I. of 6-11.2 mg.L) for ENB in Daphnia magna. US EPA ECOSAR software (v1.00a) estimates the 48 -hr daphnia EC50 for VNB substance to be 2.48mg/l and the surrogate read across substance ENB to be 2.25 mg/L, based on structure activity relationship models for neutral organic compounds. Since the QSAR predicts the toxicity of ENB and VNB to be similar with the former the marginally more toxic, it seems both reasonable and conservative to select the key parameter from the measured data using the read across substance ENB.
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