Registration Dossier

Administrative data

Key value for chemical safety assessment

Effects on fertility

Effect on fertility: via oral route
Endpoint conclusion:
no study available
Additional information
Short description of key information:
As p-PP is an intermediate only occupational exposure may occur and this is limited by the use of RMMs and PPE to prevent dermal exposure as it has been shown to be a skin irritant and sensitiser. No significant inhalation exposure occurs due to low vapour pressure. Therefore, conduct of animal studies to investigate reproduction toxicity are scientifically unjustifiable.

Justification for selection of Effect on fertility via oral route:
Study not scientifically justified due to lack of human exposure.

Effects on developmental toxicity

Description of key information
As p-PP is an intermediate only occupational exposure may occur and this is limited by the use of RMMs and PPE to prevent dermal exposure as it has been shown to be a skin irritant and sensitiser. No significant inhalation exposure occurs due to low vapour pressure. Therefore, conduct of animal studies to investigate develpmental toxicity are scientifically unjustifiable.
Effect on developmental toxicity: via oral route
Endpoint conclusion:
no study available
Additional information
Justification for selection of Effect on developmental toxicity: via oral route:
Study not scientifically justified due to lack of human exposure.

Justification for classification or non-classification

There are no data available on potential developmental or reproduction toxicity and no classification is proposed.