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Diss Factsheets
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EC number: 202-179-2 | CAS number: 92-69-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP study, pre-dating OECD guidelines, some limitations in reporting but adequate for assessment.
- Justification for data waiving:
- other:
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- p-Phenylphenol (= p-Oxydiphenyl)
- IUPAC Name:
- p-Phenylphenol (= p-Oxydiphenyl)
- Details on test material:
- Name: p-Phenylphenol (= p-Oxydiphenyl)
Physical state: white flakes
Customer: Sparte OC
Date of order: 25/5/1979
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: SPF rats (strain: Wistar TNO W 74)
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Winkelmann, Borchen (Breeder)
- Age at study initiation: approximately 9 to 14 weeks old.
- Weight at study initiation: The male rats had an average initial body weight of 163 g.
- Housing: The rats were conventionally housed in groups of five in type III Macrolon cages on dust - free wood chippings
- Diet (e.g. ad libitum): During the study the rats received Altromin R 1324 (manufacturer: Altromin GmbH, Lage) ad libitum
- Water (e.g. ad libitum): tap water ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 1.5
- Humidity (%): approximately 60 ± 5 (relative humidity)
- Photoperiod (hrs dark / hrs light): 12 - hour light/dark cycle (artificial illumination from 7.00 to 19.00)
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Lutrol
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 20 mL/kg
- Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- 5, males only
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: at least once daily
- Frequency of weighing: at the time of dosing and end of the observation period.
- Necropsy of survivors performed: no
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No signs of toxicity and no effects on body weight gain.
Any other information on results incl. tables
- All male rats tolerated the single dose of 5 g/kg body weight without showing any symptoms.
- Bodyweight development was unaffected.
- P-Phenylphenol (= p-Oxydiphenyl) was shown to be relatively non - toxic in the acute study.Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 for male rats was >5000 mg/kg body weight. No symptoms of poisoning were observed.
- Executive summary:
Acute toxicity studies of p-Phenylphenol (= p-<Oxydiphenyl) were conducted by oral administration in male Wistar rats.
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