Registration Dossier
Registration Dossier
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EC number: 271-378-4 | CAS number: 68551-44-0
Endpoint summary
Administrative data
Description of key information
Low toxicity.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 064 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 3 000 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 3 640 mg/kg bw
Additional information
Neodecanoic acid has a low potential for toxicity via the oral, inhalation, and dermal routes.
Oral
Male and female rats were gavaged with neodecanoic acid at concentrations of 1, 1.5, 2, 3, or 4 ml/kg to assess acute oral toxicity. All animals that died during the study did so within 3 days of exposure. Signs of toxicity included lethargy, hypothermia, piloerection, dyspnea, and ataxia. Based on these results, it is concluded that the LD50 is approximately 2.27 ml/kg (2066 mg/kg).
Dermal
In a study that assessed acute dermal toxicity, male and female rats were exposed to 4 ml/kg (3640 mg/kg) neodecanoic acid via an occluded dermal patch for 24 hours. After 24 hours, the patch was removed and clinical observations were made once daily for 9 days. There were no deaths observed in this study and there were no signs of a toxicity response. It is concluded that the LD50 is greater than 3640 mg/kg.
Inhalation
In acute inhalation study, male Wistar rats and Swiss albino mice (10/sex/species) were exposed the test substance vapour via a whole-body exposure at 3.0 mg/L for 6 hours with a subsequent 14 day observation period. No mortality or significant signs of toxicity were observed during the 6-hour exposure period. No deaths occurred in mice or rats throughout the study and no significant observations were made at necropsy. The LC50 is therefore greater than 3 mg/l (3000 mg/m3).
Justification for classification or non-classification
No classification for acute toxicity (dermal or inhalation) is indicated according to the general classification and labelling requirements for dangerous substances and preparations (Directive 67-548-EEC) or the classification, labelling and packaging (CLP) regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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