Registration Dossier
Registration Dossier
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EC number: 939-525-3 | CAS number: 1471313-03-7
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
In vitro studies were GLP compliant and of high quality (Klimisch score = 1). Therefore there is no reason to believe that these results would not be applicable to humans.
Justification for selection of genetic toxicity endpoint
No study was selected as all three in vitro studies were used as a weight of evidence for this endpoint.
Short description of key information:
Ames test (OECD guideline 471): negative with and without metabolic activation
In vitro chromosome aberration test performed with cultured human lymphocytes: negative with and without metabolic activation
In vitro mammalian cell gene mutation test with mouse lymphoma L5178Y tk +/- cells: negative with and without metabolic activation
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
The substance was negative in three in vitro studies : gene mutation in bacteria, chromosome aberration test and gene mutation in mammalian cells. Therefore the substance is not classified according to Directive 67/548/EEC and CLP Regulation (EC) N° 1272 /2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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