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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2021-09-07 to 2021-10-18
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Version / remarks:
adopted July 27, 1995
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient - Shake Flask Method)
Deviations:
no
Qualifier:
according to guideline
Guideline:
other: OECD guideline for the testing of chemicals: Water Solubility, Guideline No.: 105
Version / remarks:
adopted July 27, 1995
Deviations:
no
GLP compliance:
no
Type of method:
estimation method (solubility ratio)
Partition coefficient type:
octanol-water
Analytical method:
analysis (not specified)
other: observation of undissolved particles (for octanol)
Key result
Type:
log Pow
Partition coefficient:
< -1.6
Temp.:
20 °C
pH:
> 0 - < 14
Remarks on result:
other: The pH is not particularly mentioned in the study report, however it is being assumed that the study was conducted under regular pH conditions.
Details on results:
Undissolved particles were still observed in the test item / n-octanol mixture at the concentration 5.2 mg test item / 2 L n-octanol after 24 hours, thus, the solubility of the examined test item batch in n-octanol is less than 2.6 mg/L. The solubility of the same batch in water is 114.4 mg/L. Based on these results the log Pow of < -1.6 is calculated.
Conclusions:
Based on the individual solubility of test item in n-octanol and water, the log Pow is <-1.6.

Description of key information

Based on the individual solubility of test item in n-octanol and water, the Pow is <0.023 and the log Pow < -1.6.

Key value for chemical safety assessment

Log Kow (Log Pow):
-1.6
at the temperature of:
20 °C

Additional information