Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 208-970-9 | CAS number: 549-56-4
Endpoint summary
Administrative data
Description of key information
Additional information
Short-term toxicity of quinine sulphate to fish:
This experimental study was published by Ali, 2012. A test of the toxicity of quinine sulphate on zebrafish embryosDanio reriowas performed in a static system. The LC50 (96 h) of quinine sulphate for zebrafish embryos is 562.4 mg/L. After exposure duration of 24 h, 48 h and 72 h to 480 mg/L no embryos had died.
Short-term toxicity of quinine sulphate to invertebrates Daphnia magna and Penaeus setiferus:
This experimental study was published by Guilhermino, 2000. In this publication the EC50 for Daphnia magna was determined with an Acute Daphnia toxicity test. The EC50 (24 h) of quinine sulphate for Daphnia magna is 44.8 mg/l. In an own study the EC50 for Daphnia magna was determined with an Acute Daphnia toxicity test for 48 h. The EC50 (48 h) of quinine sulphate for Daphnia magna is 91.93 mg/l. In the ECOTOX Database, the toxicity of quinine bisulphate to Penaeus setiferus is shown. The LC100 (24h) of quinine bisulphate is 40 mg/L and the LC0 is 5 mg/L. The LC50 of quinine bisulphate for Penaeus setiferus is 13.1 mg/L.
Short-term toxicity of quinine sulphate to green algae Dunaliella salina:
This experimental study was published by Moreno-Garrido, 2001. In this publication, the toxicity to green algae Dunaliella salina was determined with a Toxicity test for 72 h, saltwater. The determined EC50 of quinine sulphate is 14.5 mg/L.
Toxicity of quinine to aquatic plants (ciliates):
This experimental study was published by Moreno-Garrido, 2001. In this publication, the toxicity of quinine sulphate for ciliates was determined for 24 h in saltwater. The determined LC100 of quinine sulphate is 12 -14 mg/L.
Estimation by calculation
The toxicity (LC50 and chronic toxicity value) is estimated by using ECOSAR v1.11. Two models are available, the estimation form the ECOSAR Class (Benzyl Alcohols) and the Neutral Organic Structure Analysis Relationship (baseline toxicity). In general, the values for toxicity estimated by Neutral Structure SAR are higher and therefore, the estimated toxicity lower compared to the estimation based on ECOSAR class (Benzyl Alcohols). Lowest LC/EC50 and chronic toxicity value, were observed for green algae, at 32.928 g/L and 5.404 g/L, respectively. Estimation by calculation only provides an approximation. The EPA recommends that empirical measures provide better results.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
