Registration Dossier
Registration Dossier
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EC number: 482-400-9 | CAS number: 138776-88-2
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin: A 4 -hour application of 0.5g of the substance (moistened with corn oil) to occluded rabbit skin resulted in no erythema, edema or other reaction on any of 6 animals. All dosed sited remained unaffected throughout the 7 day observation period.
Eye: Instillation of 50 mg of sample (equivalent of 0.1 ml) into rabbit eyes resulted in no corneal injury in any of 6 animals. Iritis was apparent in 3 animals and minor conjunctival irritation developed in 6 rabbits. Substantial ocular discharge was evident in 3 animals. After 24 hours, all rabbit eyes exhibited a normal appearance.
Justification for classification or non-classification
Skin irritation: according to EEC Council Directive 67/548/EEC (amended by Directive 83/467/EEC) and GHS/CLP the mean values for erythema and edema scores were less than 2 for all animals tested. According to annex VI and I of these directives diisobutyl ketone is not classified as skin irritant.
Eye irritation: according to the annex VI of the council directive 67/548 EEC (amended by directive 83/467 EEC) the average scores over all animals cornea opacity, iris lesions, conjunctivae and chemosis were 0 at all, respectively at 24, 48 and 72 hours. According to EU criteria no classification for eye irritancy is required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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