Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1993

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Tris(4-aminophenyl) thiophosphate
EC Number:
258-083-6
EC Name:
Tris(4-aminophenyl) thiophosphate
Cas Number:
52664-35-4
Molecular formula:
C18H18N3O3PS
IUPAC Name:
O,O,S-tris(4-aminophenyl) thiophosphate

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White
Details on test animals or tissues and environmental conditions:
Batch: S0067/S 0069, Assay 99.2 %

Test system

Vehicle:
unchanged (no vehicle)
Controls:
other: opposite eye
Duration of treatment / exposure:
24 h
Observation period (in vivo):
1h, 24h, 48h, 72h, 7d
Number of animals or in vitro replicates:
3

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Remarks:
cornea, fluorescein, iris conjunctivae, aqueous humour discharge
Basis:
mean
Time point:
other: 1h, 24h, 48h, 72h, 7d
Score:
0
Max. score:
0

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information