Registration Dossier
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EC number: 224-832-0 | CAS number: 4511-42-6
Solubility in organic solvents / fat solubility
Administrative data
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2009-09-03 to 2009-10-08
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP study, but no guideline followed
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report Date:
- 2009
Materials and methods
- GLP compliance:
- yes (incl. certificate)
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Type:
- Constituent
- Test material form:
- solid: flakes
- Details on test material:
- - Name of test material (as cited in study report): LL Lactide
- Batch no: 0902000694
- Purity 100 %
- Expiration date of the lot/batch: 2010-02-10
- Stability under storage conditions: stable
- test substance storage: at room temperature in the dark
- sample density: 1.33 g/cm3
Results and discussion
Solubility in organic solvents / fat solubilityopen allclose all
- Medium:
- other: sunflower oil
- Solubility:
- other: insoluble
- Remarks on result:
- other: insoluble, well dispersed
- Medium:
- other: silicone oil
- Solubility:
- other: insoluble
- Remarks on result:
- other: insoluble, well dispersed
- Medium:
- other: kerosene
- Solubility:
- other: insoluble
- Remarks on result:
- other: insoluble, but poor dispersion stability
- Medium:
- toluene
- Solubility:
- other: soluble
Applicant's summary and conclusion
- Conclusions:
- In conclusion, it can be stated that LL-lactide is insoluble in kerosene, silicone oil and vegetable oils, but soluble in toluene.
- Executive summary:
The solubility of the test item in organic solvents was assesed in a GLP non-guideline study. A small quantity of the test item sample was added to 25 mL of different solvents and the mixtures were vortexed for 10 seconds. LL lactide is insoluble in kerosene, silicone oil and vegetable oil, but soluble in toluene.
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