Registration Dossier
Registration Dossier
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EC number: 221-657-1 | CAS number: 3179-47-3
Endpoint summary
Administrative data
Description of key information
There is no information concerning acute toxicity for n-Decyl methacrylate available. The results of acute toxicity studies of the structurally closely related Isodecyl methacrylate (i-C10-Ester) are considered as representative for acute toxicity of n-Decyl methacrylate (n-C10 -Ester).
The acute toxicity of Isodecyl methacrylate was demonstrated to be low by the oral and dermal route. The absence of inhalation toxicity was demonstrated in a study where test animals were exposed to a saturated atmosphere. However, the inhalation route is not of relevance due to the low vapour pressure of Isodecyl methacrylate and n-Decyl methacrylate.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- The key study is not GLP compliant and has Klimisch score 2. OSHA toxicity screening test.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- The key study is not GLP compliant and has Klimisch score 2. OSHA toxicity screening test.
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 3 000 mg/kg bw
- Quality of whole database:
- The key study is not GLP compliant and has Klimisch score 2. OSHA toxicity screening test.
Additional information
There is no information concerning acute toxicity for n-Decyl methacrylate available. The results of acute toxicity studies of the structurally closely related Isodecyl methacrylate (i-C10-Ester) are considered as representative for acute toxicity of n-Decyl methacrylate (n-C10 -Ester).
The acute toxicity of Isodecyl methacrylate by the oral and dermal route was demonstrated to be low in animal tests with rats and rabbits. The results are confirmed by read-across to the structural closely related substances 2-Ethylhexyl methacrylate (C8 Methacrylate ester) and Dodecyl methacrylate (C12 Methacrylate ester) The absence of inhalation toxicity was demonstrated in a study where test animals were exposed to a saturated atmosphere. However, the inhalation route is not of relevance due to the low vapour pressure of the substance.
Justification for selection of acute toxicity – oral endpoint
No studies are available for n-Decyl methacrylate. Based on molecular structure, molecular weight, water solubility, and octanol-water partition
coefficient it can be expected that oral absorption rates are of the same order of magnitude like the structurally closely related Isodecyl methacrylate (i-C10-Ester). Therefore the study of Isodecyl methacvrylate is considered as representative for acute oral toxicity of n-Decyl methacrylate (n-C10 -Ester).
Justification for selection of acute toxicity – inhalation endpoint
No studies are available for n-Decyl methacrylate. Based on molecular structure, molecular weight, low vapour pressure it can be expected that inhalative absorption rates are of the same order of magnitude like the structurally closely related Isodecyl methacrylate (i-C10-Ester). Therefore the study of Isodecyl methacvrylate is considered as representative for acute inhalative toxicity of n-Decyl methacrylate (n-C10 -Ester).
The absence of inhalation toxicity was demonstrated in a study where test animals were exposed to a saturated atmosphere. In that OSHA toxicity screening test in Albino rats on acute inhalation toxicity with Isodecyl methacrylate, no mortalities, behavioral abnormalities or gross pathologic alterations were observed after one hour exposure within a 14 day observation period. The determined LC0 was > 0.9 mg/L at 35 °C (saturated atmosphere). However, the inhalation route is not of relevance due to the low vapour pressure of the substance.
Justification for selection of acute toxicity – dermal endpoint
No studies are available for n-Decyl methacrylate. Based on molecular structure, molecular weight, water solubility, and octanol-water partition
coefficient it can be expected that dermal absorption rates are of the same order of magnitude like the structurally closely related Isodecyl methacrylate (i-C10-Ester). Therefore the study of Isodecyl methacvrylate is considered as representative for acute dermal toxicity of n-Decyl methacrylate (n-C10 -Ester).
Justification for classification or non-classification
According to the criteria as of directive 1272/2008/EC, no classification is warranted for the acute toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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